Osteoarthritis of finger joints in Finns aged 30 or over: prevalence, determinants, and association with mortality

Haara, Mikko

doi:10.1136/ard.62.2.151

Cited by 172 publications

(140 citation statements)

References 49 publications

(50 reference statements)

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“…When contrasting this study's findings with those of population-based surveys conducted in the Western populations, the prevalence of spine and shoulder OA was relatively higher [3,18,34,35], whereas the prevalence of hip and hand OA was lower [5,11,13,27,28,30,40] and that of knee OA was similar to or slightly higher than that of the Western populations (Table 3) [5,10,22,28]. In comparison with studies on other Asian populations, the prevalence of hip, knee, shoulder, and hand OA was similar [7,15,26,27,39,40], whereas the prevalence of spine OA was slightly lower than the reported prevalence [24].…”

Section: Discussioncontrasting

confidence: 38%

“…On the other hand, we also found a higher prevalence of hand OA in females compared with males, and this sex discrepancy is a universal finding [11,40]. However, when detailed comparisons were made according to pattern of joint involvement and sex, these sex disparities showed more diverse changes.…”

Section: Discussionmentioning

confidence: 57%

“…However, this female predominance was not obvious in the MCP and first CMC joints; instead, OA in the first CMC joint was found to be more common in males. In other population-based studies, female predominance in the prevalence of OA in the DIP and PIP joints was consistent regardless of geographic area studied [11,40]. However, sex difference in the prevalence of OA in the MCP and first CMC joints showed mixed results among various ethnic groups.…”

Section: Discussionmentioning

confidence: 87%

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Prevalence and Risk Factors of Spine, Shoulder, Hand, Hip, and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years

Cho

Morey

Kang

et al. 2015

Clin Orthop Relat Res

107

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Background Osteoarthritis (OA) is common and disabling among older patients around the world. Data exploring the prevalence and risk factors of OA are of paramount importance in establishing healthcare policies. However, few studies have evaluated these topics among Asian populations. Questions/purposes This study was conducted to determine the prevalence and risk factors of radiographic OA in the spine, shoulder, hand, hip, and knee in Koreans older than age 65 years.Methods A simple random sample (N = 1118) was drawn from a roster of elderly individuals older than age 65 years in Seongnam. Of the 1118 invited subjects, 696 (males = 298, females = 398) participated in this study (a response rate of 62%). The mean age of respondents was 72 ± 5 years (range, 65-91 years). Radiographs of the lumbar spine, shoulder, hand, hip, and knee were taken and afterward evaluated for radiographic OA. The KellgrenLawrence grading system was used for all mentioned joints, and radiographic OA was defined as Grade 2 changes or higher. The association of sex, aging, and obesity with OA in each of the mentioned joints was determined with the help of multivariate logistic regression. Results The highest prevalence of radiographic OA was seen in the spine (number of subjects with OA/number of whole population = 462 of 696 [66%]) followed by the hand (415 of [CI], 3.9-8.4; p \ 0.001) and hand OA (OR, 2.3; 95% CI, 1.6-3.1; p \ 0.001), and male sex was associated with spine OA (OR, 0.7; 95% CI, 0.5-1.0; p = 0.025). Aging was associated with radiographic OA in the spine, knee, and hand (OR per 5-year increments, 1.3 [95% CI, 1.1-1.6; p = 0.001], 1.6 [95% CI, 1.4-1.9; p \ 0.001], and 1.4 [95% CI, 1.2-1.7; p \ 0.001]), respectively) but not associated with OA in the hip and shoulder. Obesity was associated with knee OA (OR, 3.4; 95% CI, 2.4-5.0; p \ 0.001) and spine OA (OR, 1.5; 95% CI, 1.1-2.2; p = 0.014) but not with OA in other joints. Conclusions OA of the spine, hand, and knee is likely to become a major public health problem rather than shoulder and hip OA in Korea. Associations of demographic factors

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Section: Discussioncontrasting

confidence: 38%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 87%

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Prevalence and Risk Factors of Spine, Shoulder, Hand, Hip, and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years

Cho

Morey

Kang

et al. 2015

Clin Orthop Relat Res

107

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“…Kalichman et al (2006) found a statistically significant association between radiographic hand OA and ischemic heart disease and gastrointestinal diseases. OA is also associated with a higher risk of mortality independent of age and comorbidities (Munger et al 1999;Haara et al 2003Haara et al , 2004.…”

Section: Biomarkers Of Agingmentioning

confidence: 99%

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Karasik

2010

AGE

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Genetic study can provide insight into the biologic mechanisms underlying inter-individual differences in susceptibility to (or resistance to) organisms' aging. Recent advances in molecular genetics and genetic epidemiology provide the necessary tools to perform a study of the genetic sources of biological aging. However, to be successful, the genetic study of a complex condition requires a heritable phenotype to be developed and validated. Genome-wide association studies offer an unbiased approach to identify new candidate genes for human diseases. It is hypothesized that convergent results from multiple aging-related traits will point out the genes responsible for the general aging of the organism. This perspective focuses on the musculoskeletal aging as an example of an approach to identify a downstream common pathway that summarizes aging processes. Since the musculoskeletal traits are linked to the state of many vital functions, disability, and ultimately survival rates, we postulate that there is significance in studying musculoskeletal aging. Construction of an integrated phenotype of aging can be achieved based on shared genetics among multiple musculoskeletal biomarkers. Valid biomarkers from other systems of the organism should be similarly explored. The new composite aging score needs to be validated by determining whether it predicts all-cause mortality, incidences of major chronic diseases, and disability late in life. Comprehensive databases on biomarkers of musculoskeletal aging in multiple large cohort studies, along with information on various health outcomes, are needed to validate the proposed measure of biological aging.

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“…Rheumatoid arthritis (RA) is a chronic, progressive, and disabling autoimmune disease that is the second most common type of arthritis, affecting 0.8% of the UK adult population. Patients with OA or RA are at significantly higher risk of cardiovascular (CV) morbidity and mortality compared with the general population 2,3,4,5,6,7,8 . Hypercholesterolemia is one of the established CV risk factors with an increased prevalence among patients with OA or RA.…”

mentioning

confidence: 99%

Effectiveness of Statins on Total Cholesterol and Cardiovascular Disease and All-cause Mortality in Osteoarthritis and Rheumatoid Arthritis

Sheng

Murphy²,

MacDonald³

et al. 2011

J Rheumatol

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Objective.There is increasing prevalence of hypercholesterolemia among patients with osteoarthritis (OA) and rheumatoid arthritis (RA). We examined the effectiveness of statins on total cholesterol (TC), cardiovascular (CV) morbidity, and mortality in patients with OA or RA.Methods.A population-based cohort study was done using a record-linkage database in Tayside, Scotland. In total, 2024 OA or RA patients who had at least 2 separate TC measurements between 1993 and 2007 were studied. They were categorized into statin-exposed and statin-unexposed groups according to statin use status during followup. The main outcomes were TC concentration change from baseline, CV events, and all-cause mortality during the followup. Multivariate Cox regression models with a time-dependent variable for statins were employed to assess the risk of outcomes.Results.Statin-associated TC concentrations in OA decreased by 15% in patients without CV disease (primary prevention, n = 1269) and 7% in patients with CV disease (secondary prevention, n = 247) from baseline of 5.30 mmol/l and 4.54 mmol/l, respectively. Correspondingly, in RA TC was reduced by 16% (n = 430) and 15% (n = 78) with baselines of 5.54 mmol/l and 4.95 mmol/l. In primary prevention, statins were associated with reduced CV events and all-cause mortality in RA patients [adjusted HR 0.45 (95% CI 0.20–0.98) and 0.43 (95% CI 0.20–0.92), respectively] and all-cause mortality in OA patients [adjusted HR 0.43 (95% CI 0.25–0.72)]. Statins were not associated with reduced risk of CV events or all-cause mortality in the secondary prevention of RA or OA patients [adjusted HR 0.68 (95% CI 0.30–1.54) and 0.52 (95% CI 0.20–1.34) for OA patients, and HR 0.58 (95% CI 0.07–4.79) and 0.79 (95% CI 0.18–3.53) for RA patients].Conclusion.Statins reduced TC concentrations between 7% and 16% in patients with OA or RA. Statins were associated with reduced CV events and mortality in RA and mortality in OA in primary prevention.

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Osteoarthritis of finger joints in Finns aged 30 or over: prevalence, determinants, and association with mortality

Cited by 172 publications

References 49 publications

Prevalence and Risk Factors of Spine, Shoulder, Hand, Hip, and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years

Prevalence and Risk Factors of Spine, Shoulder, Hand, Hip, and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Effectiveness of Statins on Total Cholesterol and Cardiovascular Disease and All-cause Mortality in Osteoarthritis and Rheumatoid Arthritis

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