Osseointegration of hydroxyapatite and remodeling‐resorption of tricalciumphosphate ceramics

Draenert, M.E.; Draenert, A.; Draenert, K.

doi:10.1002/jemt.22176

Cited by 39 publications

(33 citation statements)

References 53 publications

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“…Briefly, when compared to both α- and β-TCP, HA is a more stable phase under the physiological conditions, as it has a lower solubility (Table 1) and, thus, a slower resorption kinetics [137,138,139,140]. Therefore, the BCP concept is determined by the optimum balance of a more stable phase of HA and a more soluble TCP.…”

Section: Bioceramics Of Calcium Orthophosphatesmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

222

153

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Various types of grafts have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In principle, bioceramics can be prepared from diverse materials but this review is limited to calcium orthophosphate-based formulations only, which possess the specific advantages due to the chemical similarity to mammalian bones and teeth. During the past 40 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the calcium orthophosphate-based implants remain biologically stable once incorporated into the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed and such formulations became an integrated part of the tissue engineering approach. Now calcium orthophosphate scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous and harbor different biomolecules and/or cells. Therefore, current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery. Perspective future applications comprise drug delivery and tissue engineering purposes because calcium orthophosphates appear to be promising carriers of growth factors, bioactive peptides and various types of cells.

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Section: Bioceramics Of Calcium Orthophosphatesmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

222

153

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“…Furthermore, in contrast to traditional ceramics, hydrogels can serve as delivery vehicles for bioactive substances such as growth factors and enzymes. As mineralized hydrogels consist mainly of water and contain a polymer component, they are expected to undergo more rapid degradation than 'traditional' calcium phosphates, such as β ‐tricalcium phosphate ( β ‐TCP) and hydroxyapatite (HA), whose resorption remains incomplete after several months or even years (Draenert et al ., ; Gunther et al ., ; Hwang et al ., ; Moore et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Generation of composites for bone tissue-engineering applications consisting of gellan gum hydrogels mineralized with calcium and magnesium phosphate phases by enzymatic means

Douglas

Krawczyk

Pamuła

et al. 2014

J Tissue Eng Regen Med

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Mineralization of hydrogels, desirable for bone regeneration applications, may be achieved enzymatically by incorporation of alkaline phosphatase (ALP). ALP-loaded gellan gum (GG) hydrogels were mineralized by incubation in mineralization media containing calcium and/or magnesium glycerophosphate (CaGP, MgGP). Mineralization media with CaGP:MgGP concentrations 0.1:0, 0.075:0.025, 0.05:0.05, 0.025:0.075 and 0:0.1 (all values mol/dm , denoted A, B, C, D and E, respectively) were compared. Mineral formation was confirmed by IR and Raman, SEM, ICP-OES, XRD, TEM, SAED, TGA and increases in the the mass fraction of the hydrogel not consisting of water. Ca was incorporated into mineral to a greater extent than Mg in samples mineralized in media A-D. Mg content and amorphicity of mineral formed increased in the order A < B < C < D. Mineral formed in media A and B was calcium-deficient hydroxyapatite (CDHA). Mineral formed in medium C was a combination of CDHA and an amorphous phase. Mineral formed in medium D was an amorphous phase. Mineral formed in medium E was a combination of crystalline and amorphous MgP. Young's moduli and storage moduli decreased in dependence of mineralization medium in the order A > B > C > D, but were significantly higher for samples mineralized in medium E. The attachment and vitality of osteoblastic MC3T3-E1 cells were higher on samples mineralized in media B-E (containing Mg) than in those mineralized in medium A (not containing Mg). All samples underwent degradation and supported the adhesion of RAW 264.7 monocytic cells, and samples mineralized in media A and B supported osteoclast-like cell formation. Copyright © 2014 John Wiley & Sons, Ltd.

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“…According to the previous studies, HA is of great biocompatibility and favorable osteogenic potential because of its most similarity to the mineral part of bone and dentin [11,12], but it is characterized with poor biodegradability [13,14]. On the other hand, β-TCP is found to degrade more quickly under the effect of body fluids than HA [15,16].…”

Section: Introductionmentioning

confidence: 94%

“…The residual weight may attribute to the sodium and sulfur ions which cannot be burned out. These ions will remain on the scaffolds after calcination, but they have no influence on the cytological properties of the porous BCP scaffolds observed by the following investigation.In order to optimize the thermal treatment profile and avoid cracks causing by the removal of SDS and PMMA powders when heated in air, TGA of the green scaffold14 body is also conducted and the result is shown inFig. 5.…”

mentioning

confidence: 99%