Osmotherapy for malignant cerebral edema in a phase 2 prospective, double blind, randomized, placebo-controlled study of IV glibenclamide

Hinson, Holly E.; Sun, Elizabeth; Molyneaux, Bradley J.; Kummer, Rüdiger von; Demchuk, Andrew M.; Romero, Javier; Kimberly, W. Taylor; Sheth, Kevin N

doi:10.1016/j.jstrokecerebrovasdis.2020.104916

Cited by 5 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pragmatic therapeutic strategies for brain edema such as acupuncture, osmotherapy, non-peptide vasopressin receptor antagonist, and calcium channel blockers are used in clinical practice (Rowland et al, 2019;Corry et al, 2020;Hinson et al, 2020;Guo et al, 2022). Although the above-mentioned treatment approaches have been well-studied and display partial protective effects in attenuating cerebral edema, a single therapy capable of inhibiting cerebral edema is yet to be found due to the complex mechanisms involved.…”

Section: Melatonin and Blood-brain Barrier Disruptionmentioning

confidence: 99%

Melatonin as a Potential Neuroprotectant: Mechanisms in Subarachnoid Hemorrhage-Induced Early Brain Injury

2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease with high mortality and disability rates. Despite progressive advances in drugs and surgical techniques, neurological dysfunction in surviving SAH patients have not improved significantly. Traditionally, vasospasm has been considered the main cause of death and disability following SAH, but anti-vasospasm therapy has not benefited clinical prognosis. Many studies have proposed that early brain injury (EBI) may be the primary factor influencing the prognosis of SAH. Melatonin is an indole hormone and is the main hormone secreted by the pineal gland, with low daytime secretion levels and high nighttime secretion levels. Melatonin produces a wide range of biological effects through the neuroimmune endocrine network, and participates in various physiological activities in the central nervous system, reproductive system, immune system, and digestive system. Numerous studies have reported that melatonin has extensive physiological and pharmacological effects such as anti-oxidative stress, anti-inflammation, maintaining circadian rhythm, and regulating cellular and humoral immunity. In recent years, more and more studies have been conducted to explore the molecular mechanism underlying melatonin-induced neuroprotection. The studies suggest beneficial effects in the recovery of intracerebral hemorrhage, cerebral ischemia-reperfusion injury, spinal cord injury, Alzheimer’s disease, Parkinson’s disease and meningitis through anti-inflammatory, antioxidant and anti-apoptotic mechanisms. This review summarizes the recent studies on the application and mechanism of melatonin in SAH.

show abstract

Section: Melatonin and Blood-brain Barrier Disruptionmentioning

confidence: 99%

Melatonin as a Potential Neuroprotectant: Mechanisms in Subarachnoid Hemorrhage-Induced Early Brain Injury

2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

Sirtuins as Potential Targets for Neuroprotection: Mechanisms of Early Brain Injury Induced by Subarachnoid Hemorrhage

Lei,

Wu,

Wang

et al. 2023

Transl. Stroke Res.

View full text Add to dashboard Cite

Subarachnoid hemorrhage (SAH) is a prevalent cerebrovascular disease with significant global mortality and morbidity rates. Despite advancements in pharmacological and surgical approaches, the quality of life for SAH survivors has not shown substantial improvement. Traditionally, vasospasm has been considered a primary contributor to death and disability following SAH, but anti-vasospastic therapies have not demonstrated significant benefits for SAH patients' prognosis. Emerging studies suggest that early brain injury (EBI) may play a crucial role in influencing SAH prognosis. Sirtuins (SIRTs), a group of NAD + -dependent deacylases comprising seven mammalian family members (SIRT1 to SIRT7), have been found to be involved in neural tissue development, plasticity, and aging. They also exhibit vital functions in various central nervous system (CNS) processes, including cognition, pain perception, mood, behavior, sleep, and circadian rhythms. Extensive research has uncovered the multifaceted roles of SIRTs in CNS disorders, offering insights into potential markers for pathological processes and promising therapeutic targets (such as SIRT1 activators and SIRT2 inhibitors). In this article, we provide an overview of recent research progress on the application of SIRTs in subarachnoid hemorrhage and explore their underlying mechanisms of action.

show abstract

Buffer Coefficient as a Predictor of the Prognosis of Massive Cerebral Infarction

Tan

Shen²,

Yang³

et al. 2022

World Neurosurgery

View full text Add to dashboard Cite

Osmotherapy for malignant cerebral edema in a phase 2 prospective, double blind, randomized, placebo-controlled study of IV glibenclamide

Cited by 5 publications

References 21 publications

Melatonin as a Potential Neuroprotectant: Mechanisms in Subarachnoid Hemorrhage-Induced Early Brain Injury

Melatonin as a Potential Neuroprotectant: Mechanisms in Subarachnoid Hemorrhage-Induced Early Brain Injury

Sirtuins as Potential Targets for Neuroprotection: Mechanisms of Early Brain Injury Induced by Subarachnoid Hemorrhage

Buffer Coefficient as a Predictor of the Prognosis of Massive Cerebral Infarction

Contact Info

Product

Resources

About