Oseltamivir, zanamivir and amantadine in the prevention of influenza: A systematic review

Rw, Jackson; Cooper, Katy; Tappenden, Paul; Rees, A; Simpson, Emma; Read, Robert C.; Nicholson, Karl G.

doi:10.1016/j.jinf.2010.10.003

Cited by 88 publications

(75 citation statements)

References 62 publications

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“…ISSN 2472-1093 [57] The DoD also stockpiles oseltamivir and zanamivir as a contingency component of its pandemic preparedness plans (AFHSB, unpublished data). In patients with severe disease (such as pneumonia or ARDS), empirical broad-spectrum antimicrobial therapy should also be initiated to cover bacterial coinfections, with appropriate de-escalation of antimicrobials when lower respiratory bacterial cultures return with definitive results [19].…”

Section: Journal Of Infectious Diseases and Treatmentmentioning

confidence: 99%

Influenza in the US Military: An Overview

Sánchez¹,

Cooper²

2016

J Infec Dis Treat

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Section: Journal Of Infectious Diseases and Treatmentmentioning

confidence: 99%

Influenza in the US Military: An Overview

Sánchez¹,

Cooper²

2016

J Infec Dis Treat

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“…3e5 Evidence from randomized controlled trials has shown that oseltamivir is effective for the prevention of laboratoryconfirmed influenza in several settings. 5,6 However, outbreak investigation and drug delivery can be very challenging, 5 especially in settings outside hospitals. As such, the authors evaluated their experience of managing outbreaks of respiratory virus infections in care homes in Essex (a county in SouthEast England) over three years.…”

Section: Introductionmentioning

confidence: 99%

Oseltamivir in influenza outbreaks in care homes: challenges and benefits of use in the real world

Millership

Cummins

2015

Journal of Hospital Infection

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“…Altough influenza vaccines are an effective weapon against influenza and are cost-saving (Peasah et al, 2013), antiviral drugs could offer an opportunity to alleviate the burden of influenza, both for treating influenza symptoms and for post-exposure prophylaxis (Jackson et al, 2011;Tappenden et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…In particular, Neuraminidase-Inhibitors (NI) such as oseltamivir and zanamivir proved to be cost-effective and clinically effective, whilst evidence for adamantanes M2-inhibitors such as amantadine and rimantadine is scarser (Jackson et al, 2011;Burch et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Docking and Molecular Dynamics (MD) Simulations in Potential Drugs Discovery: An Application to Influenza Virus M2 Protein

Bozdaganyan¹,

Orekhov²,

Bragazzi³

et al. 2014

American Journal of Biochemistry and Biotechnology

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Molecular docking is a common method for searching new potential drugs. Improvement of the results of docking can be achieved by different ways-one of them is molecular dynamics simulations of protein-ligand complexes. As a model for our research we chose M2 membrane protein from influenza virus. M2 protein is a high selective tetrameric pH-gated proton channel. It was previously shown that Omeprazole Family Compounds (OFC) block the "proton pump", though we hypothesized further that they could interfere with the mechanism of fusion of the virus envelope and endosomal membrane, thereby hindering the M2 proton pump mechanism of influenza viruses. We carried out a Molecular Dynamics (MD) simulation in order to predict constant of binding for OFC. We simulated M2 Protein (PDB code 3C9J) in complex with its ligands: Amantadine, rimantadine as positive controls and omeprazole as putative ligand. We made use of molecular docking as well as the thermodynamic integration method to estimate binding free energies of the ligands. We demonstrate that the thermodynamic integration method predicts free energies of ligand binding better than molecular docking while embedding of M2 protein in a membrane further improves the calculated free energy values. Free energy calculations imply omeprazole as a potent anti-viral drug.

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Oseltamivir, zanamivir and amantadine in the prevention of influenza: A systematic review

Cited by 88 publications

References 62 publications

Influenza in the US Military: An Overview

Influenza in the US Military: An Overview

Oseltamivir in influenza outbreaks in care homes: challenges and benefits of use in the real world

Docking and Molecular Dynamics (MD) Simulations in Potential Drugs Discovery: An Application to Influenza Virus M2 Protein

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