Oscillatory squeezing flow of a biological material

Phan‐Thien, N.; Nasseri, Simin; Bilston, Lynne E.

doi:10.1007/s003970000093

Cited by 27 publications

(20 citation statements)

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“…Shear thinning has been observed in several biological tissue types, such as heart and brain tissue (30) as well as in vocal cords (31). Although the structure and function of these tissue types are vastly different, the gross mechanical behavior is commonly governed by components in the extracellular matrix (ECM) (30,32).…”

Section: Resultsmentioning

confidence: 99%

“…Although the structure and function of these tissue types are vastly different, the gross mechanical behavior is commonly governed by components in the extracellular matrix (ECM) (30,32). Shear-thinning properties have been measured in the ECM component collagen (33,34), and, as the cuticle of C. elegans is predominantly composed of cross-linked collagen (35), the nonNewtonian results reported here might be explained by the properties of the cuticle.…”

Section: Resultsmentioning

confidence: 99%

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Viscoelastic properties of the nematode Caenorhabditis elegans , a self-similar, shear-thinning worm

Backholm

Ryu

Dalnoki-Veress

2013

Proc. Natl. Acad. Sci. U.S.A.

101

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Undulatory motion is common to many creatures across many scales, from sperm to snakes. These organisms must push off against their external environment, such as a viscous medium, grains of sand, or a high-friction surface; additionally they must work to bend their own body. A full understanding of undulatory motion, and locomotion in general, requires the characterization of the material properties of the animal itself. The material properties of the model organism Caenorhabditis elegans were studied with a micromechanical experiment used to carry out a three-point bending measurement of the worm. Worms at various developmental stages (including dauer) were measured and different positions along the worm were probed. From these experiments we calculated the viscoelastic properties of the worm, including the effective spring constant and damping coefficient of bending. C. elegans moves by propagating sinusoidal waves along its body. Whereas previous viscoelastic approaches to describe the undulatory motion have used a Kelvin-Voigt model, where the elastic and viscous components are connected in parallel, our measurements show that the Maxwell model, where the elastic and viscous components are in series, is more appropriate. The viscous component of the worm was shown to be consistent with a nonNewtonian, shear-thinning fluid. We find that as the worm matures it is well described as a self-similar elastic object with a shear-thinning damping term and a stiffness that becomes smaller as one approaches the tail.biomechanics | viscoelasticity

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Viscoelastic properties of the nematode Caenorhabditis elegans , a self-similar, shear-thinning worm

Backholm

Ryu

Dalnoki-Veress

2013

Proc. Natl. Acad. Sci. U.S.A.

101

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“…Available data on other soft tissues is comparatively sparse and more recent. Viscoelastic properties of the renal and hepatic tissues were primarily reported by Yamada (1970) and Melvin et al (1973) and much later by Farshad et al (1999); Phan-Thien et al (2000); Miller (2000); Liu et al (2000); Kauer et al (2001); Carter et al (2001); Nasseri et al (2002); Tamura et al (2002); Liu et al (2002); Kiss et al (2004); Hu et al (2004); Snedeker et al (2005); Chui et al (2007); Mazza et al (2008) and Rosen et al (2008).…”

Section: Introductionmentioning

confidence: 95%

A strain-hardening bi-power law for the nonlinear behaviour of biological soft tissues

Nicolle

Vezin

Palierne

2010

Journal of Biomechanics

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“…Similar model is also used to study the mechanical behavior of cervical spine by Myers et al (1991). Nonlinear Maxwell models are proposed to predict the behavior of kidney under large-amplitude oscillatory squeezing flow (Phan-Thien et al 2000), and to predict the properties of kidney cortex under strain sweep, small-amplitude oscillatory motion, stress relaxation, and constant shear rate tests (Nasseri et al 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Most biological tissues exhibit time-dependent, viscoelastic behavior when subject to mechanical stimuli. There are two kinds of viscoelastic models for soft tissues: microstructural (Bates 1998;Guilak and Mow 2000) and rheological models (Pinto and Fung 1973;Sanjeevi 1982;Huyghe et al 1991;Myers et al 1991;Phan-Thien et al 2000;Nasseri et al 2002). Rheological models describe the gross mechanical behavior of biological tissue in simple formulations.…”

Section: Introductionmentioning

confidence: 99%

Mechanical behavior of human embryonic stem cell pellet under unconfined compression

Petersen

Leong

et al. 2011

Biomech Model Mechanobiol

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As a prelude to the understanding of mechanotransduction in human embryonic stem cell (hESC) differentiation, the mechanical behavior of hESCs in the form of cell pellet is studied. The pellets were tested after 3 or 5 weeks of cell culture in order to demonstrate the effect of the duration of cell culture on the mechanical properties of the pellets. A micromechanical tester was used to conduct unconfined compression on hESC pellet, and experimental, numerical, and analytical methods were combined to determine the mechanical properties of hESC pellet. It is assumed that the mechanical behavior of hESC pellets can be described by an isotropic, linear viscoelastic model consisting of a spring and two Maxwell units in parallel, and the Poisson's ratio of the hESC pellet is constant based on pellet deformation in the direction perpendicular to the compression direction. Finite element method (FEM) simulation was adopted to determine the values of Poisson's ratio and the five parameters contained in the viscoelastic model. The variations of Poisson's ratio and the initial elastic modulus are found to be larger compared with those of the four other parameters. Results show that longer duration of cell culture leads to higher modulus of hESC pellet. The effect of pellet size error on the values of mechanical parameters determined is studied using FEM simulation, and it is found that the effect of size error on Poisson's ratio and initial elastic modulus is much larger than that on the other parameters.

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Oscillatory squeezing flow of a biological material

Cited by 27 publications

References 0 publications

Viscoelastic properties of the nematode Caenorhabditis elegans , a self-similar, shear-thinning worm

Viscoelastic properties of the nematode Caenorhabditis elegans , a self-similar, shear-thinning worm

A strain-hardening bi-power law for the nonlinear behaviour of biological soft tissues

Mechanical behavior of human embryonic stem cell pellet under unconfined compression

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