OS059. Blockade of the bradykinin B2 receptor in early pregnancy reduces fetal growth and trophoblast invasion in guinea-pigs

Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors

“…They reported that blockade of the B2R by systemic administration of icatibant, a bradykinin B2 receptor antagonist, prevented the beneficial effects of bone marrow mononuclear cells transplantation. It was also shown that blocking B2R in early pregnancy impairs fetal growth and transformation of the spiral arteries, supporting the role of the B2R in local physiological adaptation (29). We used a rat myocardial infarction model to determine the relationship between angiogenic factors and the two kinin receptors during angiogenesis induced by exercise.…”

Bradykinin receptor blockade restores the baroreflex control of renal sympathetic nerve activity in cisplatin‐induced renal failure rats

“…This allowed the infusion of saline (17 lL/min), a B1 receptor blocker, Lys-[des-Arg9, Leu8]-bradykinin (LBK), or a B2 receptor blocker, bradyzide (BZ), at doses of 700 ng/kg/min (in a volume of 17 lL/min) directly into the right kidney. These doses of B1 and B2 receptor blockers were adapted from previous reports in mice, guinea-pigs and dogs (Nakhostine et al 1993, Marin-Castano et al 2002, Valdes et al 2012.…”

MiR-29b-3p affects growth and biological functions of human extravillous trophoblast cells by regulating bradykinin B2 receptor

“…Studies have shown that the expression of bradykinin B2 receptor (B2R) is significantly reduced in extravillous trophoblast patients with PE [ 6 ]. Continuous subcutaneous injection of a B2R antagonist (bradyzide) can cause a transient increase in systolic blood pressure in guinea pigs in early pregnancy, and can lead to restricted progeny growth and reduced trophoblast invasion in the spiral artery [ 7 ]. In the G protein-coupled receptor superfamily, B2R has an important role and participates in various biological processes, mainly by binding to bradykinin and activating downstream signalling pathways.…”