Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors

Shen, Mei; Yu, Min; Qiu, Chengxiu; Zhang, Ge; Li, Jingya; Fang, Wei Bin; Wang, Qiwen

doi:10.1080/10641963.2021.1896725

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Stimulation-induced angiogenesis due to exercise includes angiogenic factors such as VEGF and FGF-2. It has been suggested that FGF-2 plays an important role in exercise-induced cardiac angiogenesis (14). Consistent with the results of the present study, a study was conducted on the elderly to explore the effect of 8 weeks of running on angiogenic changes and molecular mediators associated with myocardial angiogenesis.…”

Section: Discussionsupporting

confidence: 87%

The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-2 gene expression in the heart tissue of myocardial infarction rats

Abdehvand

Dehkordi

Taghian

2022

J Shahrekord Univ Med Sci

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Background and aims: The activation of inflammatory reactions is essential immediately after the onset of myocardial infarction (MI). On the other hand, the path of inflammatory activators should be controlled to prevent the recurrence of MI. In this vein, the aim of this study was to examine the effect of eight weeks of interval training and quercetin nanoliposome consumption on nuclear factor kappa B (NF-κB) and fibroblast growth factor 2 (FGF-2) gene expression in the heart tissue of MI rats. Methods: In this experimental study, 30 male rats, aged approximately 6-8 weeks, were randomly divided into five groups including MI + training, MI + supplement, MI + training + supplement, healthy control, and MI. The MI was induced by the subcutaneous injection of isoprenaline hydrochloride at a dose of 80 mg/kg. Quercetin was daily administered at a dose of 0.25 mg for 8 weeks, and interval training was performed 5 days a week. NF-κB and FGF-2 gene expressions were measured by the real-time polymerase chain reaction. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P<0.05). Results: Training significantly increased NF-κB gene expression in the MI+ training, MI + supplement, and MI + training + supplement groups (P=0.001) while significantly decreasing FGF-2 gene expression in the MI group (P=0.04). Conclusion: Interval training may prevent the negative effects of MI by reducing pro-inflammatory gene expression in the heart tissue, leading to improved cardiovascular function and the prevention of this disease.

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Section: Discussionsupporting

confidence: 87%

The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-2 gene expression in the heart tissue of myocardial infarction rats

Abdehvand

Dehkordi

Taghian

2022

J Shahrekord Univ Med Sci

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Myocardial angiogenesis induced by concurrent vitamin D supplementation and aerobic-resistance training is mediated by inhibiting miRNA-15a, and miRNA-146a and upregulating VEGF/PI3K/eNOS signaling pathway

Saati-Zarei

Damirchi

Tousi

et al. 2023

Pflugers Arch - Eur J Physiol

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Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors

Abstract: Fang & Qiwen Wang (2021): Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors, Clinical and Experimental Hypertension,

Cited by 2 publications

References 31 publications

The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-2 gene expression in the heart tissue of myocardial infarction rats

The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-2 gene expression in the heart tissue of myocardial infarction rats

Myocardial angiogenesis induced by concurrent vitamin D supplementation and aerobic-resistance training is mediated by inhibiting miRNA-15a, and miRNA-146a and upregulating VEGF/PI3K/eNOS signaling pathway

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