Myocardial angiogenesis induced by concurrent vitamin D supplementation and aerobic-resistance training is mediated by inhibiting miRNA-15a, and miRNA-146a and upregulating VEGF/PI3K/eNOS signaling pathway

Saati-Zarei, Alireza; Damirchi, Arsalan; Tousi, Seyed Mohammad Taghi Razavi; Babaei, Parvin

doi:10.1007/s00424-023-02788-x

Cited by 3 publications

(1 citation statement)

References 96 publications

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“…This vitamin D 3 effect was through the regulation of NF-κB signaling. In contrast, the stimulation with vitamin D 3 in dengue virus type 2 (DENV-2)-infected human macrophages induced the downregulation of miR-146a-5p expression [82], as well as in an infarct mouse model with aerobic-resistance training where the supplementation with vitamin D 3 promoted a downregulation of circulating miR-146a-5p [83]. The evidence suggests that the vitamin D 3 supplementation may regulate the inflammation present in asthma by the regulation of miR-146a-5p expression.…”

Section: The Role Of Microrna-155 In Asthma and Its Modulation By Vit...mentioning

confidence: 99%

The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

Hernández-Díazcouder,

Romero-Nava,

Del-Río-Navarro

et al. 2024

Nutrients

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Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported that hypovitaminosis D is frequent in patients with asthma and is associated with worsening the disease and that supplementation with vitamin D3 improves asthma symptoms. However, despite several advances in the field, the molecular mechanisms of asthma have yet to be comprehensively understood. MicroRNAs play an important role in controlling several biological processes and their deregulation is implicated in diverse diseases, including asthma. Evidence supports that the dysregulation of miR-21, miR-27b, miR-145, miR-146a, and miR-155 leads to disbalance of Th1/Th2 cells, inflammation, and airway remodeling, resulting in exacerbation of asthma. This review addresses how these molecular mechanisms explain the development of asthma and its exacerbation and how vitamin D3 may modulate these microRNAs to improve asthma symptoms.

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Section: The Role Of Microrna-155 In Asthma and Its Modulation By Vit...mentioning

confidence: 99%

The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

Hernández-Díazcouder,

Romero-Nava,

Del-Río-Navarro

et al. 2024

Nutrients

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Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression

Yu,

Zhang

2024

J. of Cardiovasc. Trans. Res.

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1,25(OH)2D3 improves diabetic wound healing by modulating inflammation and promoting angiogenesis

Ma,

Gong,

et al. 2024

The Journal of Steroid Biochemistry and Molecular Biology

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Myocardial angiogenesis induced by concurrent vitamin D supplementation and aerobic-resistance training is mediated by inhibiting miRNA-15a, and miRNA-146a and upregulating VEGF/PI3K/eNOS signaling pathway

Cited by 3 publications

References 96 publications

The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression

1,25(OH)2D3 improves diabetic wound healing by modulating inflammation and promoting angiogenesis

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