Abstract:A história da doença de Chagas se inicia no interior de Minas Gerais, com as pesquisas de um jovem médico sanitarista e pesquisador do Instituto Osvaldo Cruz: Carlos Justiniano Ribeiro Chagas (1879-1934, que em abril de 1909, comunicou ao mundo científico a descoberta de uma nova doença humana. Seu agente etiológico um protozoário que denominou de Trypanosoma cruzi, em homenagem ao seu mestre Oswaldo Cruz e o inseto transmissor, o triatomídeo conhecido como "barbeiro". Por esta descoberta, Carlos Chagas recebe… Show more
“…He performed myotomies both anteriorly and posteriorly. In 1918, De Brune, Groenveldt, and Zaaijer described the single anterior incision that is popular today [2,3]. In the 1940s, the transabdominal approach was preferred, although a transthoracic approach was also utilized.…”
Introduction Achalasia is an esophageal motility disorder characterized by disordered esophageal peristalsis with failed relaxation of the lower esophageal sphincter resulting in a functional obstruction.Treatment can include medical, endoscopic, or surgical interventions. Although none of these are curative, they each offer methods to create esophageal outflow. Materials and Methods This article discusses our preferred surgical technique used for laparoscopic Heller myotomy with Dor fundoplication. This technique has been developed over the author's career. Conclusion The technique discussed provides a safe and effective strategy to manage achalasia.
“…He performed myotomies both anteriorly and posteriorly. In 1918, De Brune, Groenveldt, and Zaaijer described the single anterior incision that is popular today [2,3]. In the 1940s, the transabdominal approach was preferred, although a transthoracic approach was also utilized.…”
Introduction Achalasia is an esophageal motility disorder characterized by disordered esophageal peristalsis with failed relaxation of the lower esophageal sphincter resulting in a functional obstruction.Treatment can include medical, endoscopic, or surgical interventions. Although none of these are curative, they each offer methods to create esophageal outflow. Materials and Methods This article discusses our preferred surgical technique used for laparoscopic Heller myotomy with Dor fundoplication. This technique has been developed over the author's career. Conclusion The technique discussed provides a safe and effective strategy to manage achalasia.
“…In the case of the Brazilian setting, it stands out among chronic diseases due to the fact that it affects approximately 1.2 million individuals 3 and because it is the fourth cause of death among infectious-parasitic diseases in the age groups over 45 years 4 .…”
Resumo Objetivou-se identificar as manifestações e as estratégias de enfrentamento da doença de Chagas que impactam na qualidade de vida do sujeito acometido. Trata-se de estudo de revisão sistemática de literatura, realizada nas bases de dados PubMed, SciELO e Lilacs, através das quais se reuniu um quantitativo de 6 artigos, além de 6 publicações identificadas por meio de verificação de lista bibliográfica e 4 trabalhos mediante busca manual, os quais foram avaliados por dois revisores de maneira independente. As variáveis tratadas foram enquadradas nos eixos temáticos: manifestações da doença de Chagas que interferem na qualidade de vida do indivíduo e estratégias de enfrentamento que impactam na qualidade de vida de pacientes acometidos por doença de Chagas, subdivididos em três dimensões: domínio físico, domínio psicológico e domínio social. Os resultados visualizados em todos os domínios tratados demonstraram qualidade de vida comprometida pelo acometimento da doença; medidas de enfrentamento limitadas, em sua maioria, à dimensão física do paciente; além de registros incipientes de estudos na área. Sugere-se a exploração da temática proposta, acreditando-se que o conhecimento do convívio do portador com a doença promove a elaboração de estratégias de intervenção em saúde eficazes.
In this work the synthesis and antiparasitical activity of new 1,5-diaryl-3-oxo-1,4-pentadienyl derivatives are described. First, compounds 1a, 1b, 1c and 1d were prepared by acid-catalyzed aldol reaction between 2-butanone and benzaldehyde, anisaldehyde, p-N,N-dimethylaminobenzaldehyde and p-nitrobenzaldehyde. Reacting each of the methyl ketones 1a, 1b, 1c and 1d with the p-substituted benzaldehydes under basic-catalyzed aldol reaction, we further prepared compounds 2a-2p. All twenty compounds were evaluated for antiproliferative activity, particularly for promastigote of Leishmania amazonensis and epimastigote of Trypanosoma cruzi. All compounds showed good activity while nitro compounds 2i and 2k showed inhibition activity at a few μM.
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