Orthotopic reimplantation of cryopreserved ovarian cortical strips after high-dose chemotherapy for Hodgkin's lymphoma

Human oocyte and ovarian tissue cryopreservation and its application

“…In humans, ovarian stimulation has successfully induced ovulation from transplanted frozen-thawed ovarian cortical tissue [113,114]. In one individual, transient restoration of spontaneous ovarian follicular development and estrogen production, but not ovulation, was observed after autotransplantation of frozenthawed ovarian tissue that derived from a cancer patient before chemotherapy and radiation therapy [115]. The first human livebirth after orthotopic transplantation of cryopreserved ovarian tissue has now been reported in a woman previously treated with chemotherapy and radiotherapy for lymphoma [9].…”

Efficacy of ovarian tissue cryopreservation in a major European center

“…Thus far, at least 30 live births have been reported following cryopreservation and autotransplantation of ovarian tissue. [1] Various methods for ovarian tissue cryopreservation and thawing [2][3][4][5][6][7][8][9] are being used worldwide. Although the efficacy of cryopreservation of ovarian tissue may thus differ from one center to another, information regarding these differences is scarce.…”

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

“…Few experimental studies have tested the human ovarian tissue from both HL or NHL and failed to show evidence of ovarian involvement by lymphoma cells [18,20,24,25]. To date, 15 auto-transplantations have been reported in HL patients and 6 in NHL without any disease recurrence, knowing that the follow-up after autotransplantation in one of the HL patients is now up to 8 years [19,[26][27][28][29][30][31][32][33][34]. Nevertheless, a recent case-report showed an ovarian involvement in the histologic examination of ovarian cortex pieces in a stage III HL [15].…”