Orthotopic homotransplantation of the human liver

Starzl, T. E.; Groth, C. G.; Brettschneider, Lawrence; Penn, Israel; Fulginiti, Vincent A.; Moon, John B.; Blanchard, H; Martin, Alessandro; Porter, K. A.

doi:10.1097/00007890-196905000-00023

Cited by 73 publications

(80 citation statements)

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“…Com mais de 30 anos de experiência desde sua introdução na prática médica, o transplante hepático evoluiu, acumulando progressos e se firmando como a única opção terapêutica eficaz no tratamento de pacientes portadores de doenças hepáticas avançadas 1,2 . O transplante de fígado melhorou sobremaneira a taxa de sobrevida das crianças e adolescentes com doença hepática terminal.…”

Section: Introductionunclassified

Pediatric liver transplantation: 10 years of experience at a single center in Brazil

Mesquita

Ferreira

Veloso³

et al. 2008

J Pediatr (Rio J)

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Section: Introductionunclassified

Pediatric liver transplantation: 10 years of experience at a single center in Brazil

Mesquita

Ferreira

Veloso³

et al. 2008

J Pediatr (Rio J)

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“…Partial dearterialization of the hepatic allograft was recognized in some of the first clinical trials of OLTx, children being particularly susceptible to this complication [8,9]. The syndrome of regional hepatic gangrene resuited often, with retention of good hepatic function in the face of the septic complication that caused death several months later.…”

Section: Discussionmentioning

confidence: 99%

Partial dearterialization of the liver allograft

Yanaga¹,

Tzakis²,

Starzl³

1990

Transplant Int

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Abstract. The clinical course of five patients with partial dearterialization of their hepatic allografts is described. One patient died and three others suffered serious morbidity as a direct or indirect result of this complication. Partial dearterialization of the liver allograft is a serious and potentially life-threatening complication for which preservation of the complete hepatic arterial supply is important' even if this requires reconstruction of the aberrant vessels. Key words: Liver transplantation, partial dearterialization -Arterial supply, in liver transplantationThe arterial blood supply of the liver is extremely variable, and the interruption of the hepatic artery is a feared complication in hepatobiliary or pancreatic surgical procedures, as well as in liver transplantation [2,7,10,11]. Although the clinical consequences of complete dearterialization of an allograft in orthotopic liver transplantation (OLTx) are well documented [10], little is known about the behavior of a partially dearterialized liver graft. We studied the clinical course of five patients who were known to have had this complication in order to clarify its significance. Patients and results Case JA 20-year-old male underwent OLTx for sclerosing cholangitis. The graft had an aberrant left hepatic artery (HA) originating from the left gastric artery (LGA) and a properHA that supplied the right hepatic lobe. Figure 1 demonstrates the postoperative course. On day 7 post-transplantation, he underwent Doppler ultrasonography of the graft, which failed to demonstrate arterial flow. Emergency

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“…After a failed trial in 1963, liver transplantation was successfully performed in humans in July 1967 (Table 4) (48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60). Hepatic replacement was initially viewed as too difficult to be technically feasible, particularly in terminally ill patients for whom artificial organ support comparable to renal dialysis was not available.…”

Section: Liver Transplantationmentioning

confidence: 99%

Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles

Groth

Brent²,

Calne

et al. 2000

World j. surg.

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The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields. However, the basic principles that made this possible were established over a three-decade period, beginning during World War II and ending in 1974. At the historical consensus conference held at UCLA in March 1999, 11 early workers in the basic science or clinical practice of transplantation (or both) reached agreement on the most significant contributions of this era that ultimately made transplantation the robust clinical discipline it is today. These discoveries and achievements are summarized here in six tables and annotated with references.The symposium making up this issue of the Journal was held at the University of California, Los Angeles (UCLA) and announced by the Department of Surgery hosts as "a unique and historic meeting at which pioneers of transplantation from around the world will present and discuss landmarks in the advancement of transplantation biology." The participants (in alphabetical order) were: Leslie B. Brent (London), Roy Y. Calne (Cambridge, UK), Jean Dausset (Paris), Robert A. Good (St. Petersburg, FL), Joseph E. Murray (Boston), Norman E.Correspondence to: Carl G. Groth. NIH Public Access Author ManuscriptWorld J Surg. Author manuscript; available in PMC 2010 November 1. Published in final edited form as:World J Surg. 2000 July ; 24(7): 834-843. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptShumway (Palo Alto), Robert S. Schwartz (Boston), Thomas E. Starzl (Pittsburgh), Paul I. Terasaki (Los Angeles), E. Donnall Thomas (Seattle), Jon J. van Rood (Leiden).Each of these 11 pioneers provided for publication their reflections about their own unique contributions. The ultimate objective, however, was to reach a consensus by the group on what were the most critical historical discoveries that made transplantation a form of clinical therapy. Carl G. Groth (Stockholm) was invited to be the Chairman for these consensus deliberations and to prepare the executive summary.Historical landmark status was restricted to contributions made at least a quarter of a century ago. By this time it had been established that rejection of organ allografts could be prevented or reversed with immunosuppressive drugs and that variable donor-specific immunologic tolerance of the graft subsequently developed in many patients. Long-term survival of human recipients of organ and bone marrow allografts had been repeatedly obtained, ensuring continuation of such clinical efforts. A large number of HLA antigens had been discovered, allowing efforts at tissue matching to proceed. The scientific articles annotating this progress are listed in six tables under the following headings: transplantation immunology, bone marrow transplantation, renal transplantation, liver transplantation, heart transplantation, and tissue matching. The material presented in these tables, including the citations, originated from the participants of the symp...

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Orthotopic homotransplantation of the human liver

Cited by 73 publications

References 0 publications

Pediatric liver transplantation: 10 years of experience at a single center in Brazil

Pediatric liver transplantation: 10 years of experience at a single center in Brazil

Partial dearterialization of the liver allograft

Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles

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