“…Our findings, which confirm a good insular function of pancreatic grafts, agree with previous studies on the subject [2,12,13,14,15,16,19,24,25,31,32]. Moreover, we have demonstrated that not only the B-cellular system but also the D-and extrainsular endocrine system are well preserved.…”
Section: Discussionsupporting
confidence: 82%
“…From 1965 onward, several contributions concerning this subject [2,9,12,13,14,15,16,19,21,24,25,28,31,32] have remarkably increased our present knowledge of its technical, biological and functional aspects.…”
“…Our findings, which confirm a good insular function of pancreatic grafts, agree with previous studies on the subject [2,12,13,14,15,16,19,24,25,31,32]. Moreover, we have demonstrated that not only the B-cellular system but also the D-and extrainsular endocrine system are well preserved.…”
Section: Discussionsupporting
confidence: 82%
“…From 1965 onward, several contributions concerning this subject [2,9,12,13,14,15,16,19,21,24,25,28,31,32] have remarkably increased our present knowledge of its technical, biological and functional aspects.…”
“…Die Pankreastransplantation als Methode zur Behandlung des in sulinpflichtigen Diabetes mellitus wurde vor 30 Jahren in Minneapolis entwickelt [1] …”
Die kombinierte Pankreas- und Nierentransplantation bei Patienten mit diabetischer Nephropathie und terminaler Niereninsuffizienz brachte im eigenen Krankengut zwischen 1973 und 1979 keine Langzeiterfolge. Von 1980 bis 1982 wurden mit derselben Indikation 13 simultane Transplantationen vorgenommen. Die Pankreastransplantation wurde in Form der Pankreassegment-Transplantation mit gleichzeitiger oder verzögerter Duktverödung durchgeführt. Fünf Patienten leben noch; bei 4 davon war die Pankreasfunktion nach 2, 5 und 9 Monaten bzw. 5 Jahren verlorengegangen. Eine Patientin lebt nach 15 Jahren mit gut funktionierendem Pankreas- und Nierentransplantat. Dieser Fall entspricht dem weltweit längsten Uberleben nach Pankreas- und Nierentransplantation.
“…A modification of this technique was used for four of the first five clinical transplants that were reported by Lillehei et al [9]. Largiader et al, in 1967, were the first to transplant successfully an entire pancreaticoduodenal allograft and establish exocrine drainage to the bowel of recipient dogs [16]. They placed the graft intra-abdominally and anastomosed the donor duodenum to a Roux-en-Y loop of recipient jejunum, with vascular anastomosis to the host aorta and inferior vena cava.…”
Section: A Transplantation Of the Pancreas With Exocrine Drainage Esmentioning
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