Pancreas and islet transplantation

Sutherland, David E.R.

doi:10.1007/bf00252624

Cited by 54 publications

(19 citation statements)

References 199 publications

(346 reference statements)

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“…The first clinical pancreas transplant was performed at the University of Minnesota in 1966 [21]. During the 1970s a few institutions performed a few cases with low success rates [22]. In 1980 the International Pancreas Transplant Registry (IPTR) was formed [23], followed by annual reports [24].…”

Section: Historymentioning

confidence: 99%

Pancreas Transplantation for Treatment of Diabetes Mellitus

2001

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Pancreas transplantation is the only treatment for type I diabetes mellitus that can induce an insulin-independent normoglycemic state. Because of the need for immunosuppression, it has been most widely applied in uremic diabetic recipients of kidney transplant with a high success rate, particularly when done as a simultaneous (SPK) procedure (insulin independence > 80% at 1 year) with patient and kidney graft survival rates equivalent to or higher than in those who receive a kidney transplant alone. The results of solitary pancreas transplants (PAK in nephropathic diabetic recipients or PTA in nonuremic recipients) have also dramatically improved; 1-year graft survival rates are more than 80% and 70%, respectively, with the new immunosuppressants tacrolimus and mycophenolate mofetil. Multiple factors are important for successful application of pancreas transplantation, as summarized in this review.

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Section: Historymentioning

confidence: 99%

Pancreas Transplantation for Treatment of Diabetes Mellitus

2001

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“…In their pioneering series, Lillehei and colleagues performed 13 pancreas transplants between December 1966 and January 1973. 2 Four pancreas transplants were performed in South America in 1968, and the first pancreas transplant in Europe was performed at Guy's Hospital in London in 1972. 2 By March 1980, only 105 pancreas transplants were performed worldwide, and the International Pancreas Transplant Registry (IPTR) was introduced.…”

Section: History Of Pancreas Transplantationmentioning

confidence: 99%

“…2 Four pancreas transplants were performed in South America in 1968, and the first pancreas transplant in Europe was performed at Guy's Hospital in London in 1972. 2 By March 1980, only 105 pancreas transplants were performed worldwide, and the International Pancreas Transplant Registry (IPTR) was introduced. 2,3 According to the IPTR, by December 31, 2021, >66 000 pancreas transplants were performed worldwide, including nearly 36 000 in the United States (Angelika Gruessner, personal communication, January 2023).…”

Section: History Of Pancreas Transplantationmentioning

confidence: 99%

“…2 By March 1980, only 105 pancreas transplants were performed worldwide, and the International Pancreas Transplant Registry (IPTR) was introduced. 2,3 According to the IPTR, by December 31, 2021, >66 000 pancreas transplants were performed worldwide, including nearly 36 000 in the United States (Angelika Gruessner, personal communication, January 2023). 4 IPTR data are based on mandatory reporting of cases in the United States and voluntary reporting outside of the United States, so non-US data may be underrepresented.…”

Section: History Of Pancreas Transplantationmentioning

confidence: 99%

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O Pancreas, Where Art Thou?

Stratta

Singh²,

Gruessner

et al. 2023

Transplantation

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“…In the best studied and documented series (18 transplants at the University of Minnesota), insulin independence for more than 4 days was never achieved. Of 74 transplants in the world, only 4 appear to have been followed by a significant period of insulin independence, and none of these transplants are currently functioning [8].…”

mentioning

confidence: 99%

Invited commentary

Naji

1984

World j. surg.

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Pancreas and islet transplantation

Cited by 54 publications

References 199 publications

Pancreas Transplantation for Treatment of Diabetes Mellitus

Pancreas Transplantation for Treatment of Diabetes Mellitus

O Pancreas, Where Art Thou?

Invited commentary

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