“…T h e apex of the heart seems to be a sensitive area of the myocardium for adrenergic stimulation, as judged from studies in rats, and isopropylnoradrenaline in high doses may even cause myocardial damage in this region (24). The fact that sympathicotonic changes in a standing position are normalized following the administration of Inderal has recently been reported by Nordenfeldt (21).…”