Orthopedic and rehabilitation aspects of eosinophilic granuloma

Langerhans’ cell histiocytosis of the spine in children with soft tissue extension and chemotherapy

“…Up to 80% of LCH lesions in children are of EG type [2]. The incidence of spinal involvement varies from 6.5% [5] to 25% [17] of cases with LCH of the skeleton. Eighty percent of cases occur in children younger than 10 years of age [4].…”

Orthopaedic · Radiology · Pathology Conference: Thigh Pain in a 53-year-Old Woman

“…The typical presentation of LCH is recent onset of pain with or without swelling in the area of a solitary bone lesion [4,[11][12][13]. Subcutaneous edema also may be visible if the lesion is in a bone with little soft tissue coverage, such as the clavicle [4].…”

“…Subcutaneous edema also may be visible if the lesion is in a bone with little soft tissue coverage, such as the clavicle [4]. Pathologic fracture complicates approximately 16% of cases [12].…”

“…Acute or active lesions typically have an osteolytic appearance with poorly defined margins without surrounding sclerosis [2,13,19]. An active lesion in a long bone often will cause medullary destruction, which may progress to endosteal scalloping, cortical erosion, or periosteal reaction [4,5,12]. The periosteal reaction can be multilayered (laminated) [2,13], which may resemble the onion skin periosteal reaction of Ewing's sarcoma.…”

Langerhans cell histiocytosis of the cervical spine in an adult: a case report

“…The lesions of LCH are most often osseous and frequently occur in the skull. Cervical spinal involvement has been reported in only a handful of cases in the literature (4,5,8,10,11).…”