Langerhans’ cell histiocytosis of the spine in children with soft tissue extension and chemotherapy

Peng, Xinsheng; Pan, Tianyue; Chen, Liyan; Huang, Gang; Wang, Jin

doi:10.1007/s00264-008-0529-8

Cited by 37 publications

(33 citation statements)

References 22 publications

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“…The differential diagnosis should include aneurysmal bone cyst, osteogenesis imperfecta, Gaucher's disease and neoplastic lesions 2 4–6. Some radiological patterns could assist the diagnosis of spinal LCH (symmetrical vertebral body collapse, maintenance of the disc spaces, absence of soft tissue masses1 6 7) but isolate spinal LCH may represent a real diagnostic challenge 4 8…”

Section: Discussionmentioning

confidence: 99%

“…Most spinal LCHs are likely to require no treatment at all 4 8–10. The endochondral ossification remains classically undisturbed3 that means the vertebral body maintains the potential for the recovery of its height 1 4 6 11.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The endochondral ossification remains classically undisturbed3 that means the vertebral body maintains the potential for the recovery of its height 1 4 6 11. Presently, radiation therapy is rarely advocated6 and chemotherapy is reserved for disseminated or aggressive diseases 4 6. Surgical treatment should be considered just in the uncommon cases of spinal cord compression2 4 5 8 9 asymmetric vertebral body breakdown with kyphosis or scoliosis3 6 8 12 and/or vertebral instability 7…”

Section: Discussionmentioning

confidence: 99%

“…Multiple localisations at different spinal levels are quite exceptional10 and paediatric patients with vertebral LCH requiring corpectomy and anterior fusion are quite uncommon 2–10. Almost all the reported anterior approaches to spinal LCH concern the cervical level and thoracic corpectomies have been previously reported only in two patients 4 9. Anterior approaches at two different levels (both thoracic) have been reported only in one patient but to perform curettage rather than corpectomy 6…”

Section: Discussionmentioning

confidence: 99%

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Paediatric spinal Langerhans cell histiocytosis requiring corpectomy and fusion at C7 and at Th8–Th9 levels

et al. 2012

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An 11-year-old girl was treated by corpectomy and anterior fusion because of the destruction of the C7 vertebral body. Pathological studies were not conclusive. The outcome was excellent, but 18 months later, she required thoracic corpectomy with anterior fusion owing to the impending kyphotic fracture of the Th8 vertebral body. Langerhans cell histiocytosis was now recognised and chemotherapy was given. 3 years later, the disease appears well controlled with normal shape of both the operated vertebral levels and maintenance of the movements of the adjacent vertebrae.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Paediatric spinal Langerhans cell histiocytosis requiring corpectomy and fusion at C7 and at Th8–Th9 levels

et al. 2012

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Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures

Bielamowicz,

Dimitrion,

Abla

et al. 2024

Cancer

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Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by lesions with CD1a‐positive/Langerin (CD207)‐positive histiocytes and inflammatory infiltrate that can cause local tissue damage and systemic inflammation. Clinical presentations range from single lesions with minimal impact to life‐threatening disseminated disease. Therapy for systemic LCH has been established through serial trials empirically testing different chemotherapy agents and durations of therapy. However, fewer than 50% of patients who have disseminated disease are cured with the current standard‐of‐care vinblastine/prednisone/(mercaptopurine), and treatment failure is associated with long‐term morbidity, including the risk of LCH‐associated neurodegeneration. Historically, the nature of LCH—whether a reactive condition versus a neoplastic/malignant condition—was uncertain. Over the past 15 years, seminal discoveries have broadly defined LCH pathogenesis; specifically, activating mitogen‐activated protein kinase pathway mutations (most frequently, BRAFV600E) in myeloid precursors drive lesion formation. LCH therefore is a clonal neoplastic disorder, although secondary inflammatory features contribute to the disease. These paradigm‐changing insights offer a promise of rational cures for patients based on individual mutations, clonal reservoirs, and extent of disease. However, the pace of clinical trial development behind lags the kinetics of translational discovery. In this review, the authors discuss the current understanding of LCH biology, clinical characteristics, therapeutic strategies, and opportunities to improve outcomes for every patient through coordinated agent prioritization and clinical trial efforts.

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Spinal Langerhans Cell Histiocytosis (Eosinophilic Granuloma)

Akhaddar

2023

Atlas of Sciatica

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Langerhans’ cell histiocytosis of the spine in children with soft tissue extension and chemotherapy

Abstract: The objectives of this paper were to look

Cited by 37 publications

References 22 publications

Paediatric spinal Langerhans cell histiocytosis requiring corpectomy and fusion at C7 and at Th8–Th9 levels

Paediatric spinal Langerhans cell histiocytosis requiring corpectomy and fusion at C7 and at Th8–Th9 levels

Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures

Spinal Langerhans Cell Histiocytosis (Eosinophilic Granuloma)

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