Orthogonal Halogen‐Bonding‐Driven 3D Supramolecular Assembly of Right‐Handed Synthetic Helical Peptides

Teng, P. K.; Gray, Geoffrey; Zheng, Mengmeng; Singh, Sylvia; Li, Xiaopeng; Wojtas, Łukasz; Vaart, Arjan van der; Cai, Jianfeng

doi:10.1002/anie.201903259

Cited by 40 publications

(56 citation statements)

References 75 publications

(22 reference statements)

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“…They are known to influence the cell–cell communication by receptor bindings and are involved in many biochemical processes such as metabolism, pain, and reproduction. [ 25 ] Besides the physiological functions of natural peptides, rationally designed synthetic peptides or screened peptide libraries are becoming extremely useful as recognition entities, [ 26–28 ] in self‐assembling nanostructures [ 29–34 ] and other hybrid materials. [ 12,35–37 ] The major advantages of considering peptides as potential candidates for designing novel recognition entities or receptors are summarized below.…”

Section: Interactive Peptide and Aunp Conjugatesmentioning

confidence: 99%

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

et al. 2020

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Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing‐related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide–AuNP‐based bio‐nano‐technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide–gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide–gold nanomaterials with functional properties are discussed along with future challenges and opportunities.

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Section: Interactive Peptide and Aunp Conjugatesmentioning

confidence: 99%

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

et al. 2020

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“…[74][75][76][77] Physical/chemical molecular modification and molecular self-assembly are effective measures for designing material structures to improve their properties. [4,42,[78][79][80] For example, molecular self-assembly via the establishment of various intermolecular noncovalent methods, including hydrogen bonding, [81,82] van der Waals forces, [83] weak coordination bonds, [84] and other methods, [85][86][87] provides an elegant and adjustable strategy for designing functional materials with unique properties (Figure 1d-f). In addition, by using homogeneous cellulose systems in the form of single molecular chains, a variety of cellulose-based functional materials have been developed, including conductive ionic gels, transparent film conductors, electroactive materials, nanovesicles, and bionic memory muscles (Figure 2).…”

Section: Molecular Design Strategy For Cellulose-based Functional Matmentioning

confidence: 99%

Molecular‐Scale Design of Cellulose‐Based Functional Materials for Flexible Electronic Devices

Pang

Jiang

Zhou

et al. 2020

Adv Elect Materials

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Structural design and self‐assembly at the molecular level provide feasible strategies for constructing materials with novel and unique properties. Cellulose is one of the most abundant bioresources and is renewable, biodegradable, biocompatible, and environmentally friendly. The formation of hydrogen‐bonding networks between the cellulose molecular chains on the one hand gives cellulose a rigid crystalline region and high mechanical strength and on the other hand it causes inconvenience to material design based on the molecular scale. The emergence of eco‐friendly solvents such as ionic liquids and alkali/urea solutions breaks the hydrogen bonds and allows the design of various cellulose‐based functional materials, such as membranes, gels, fibers, and nano/microspheres via structural optimization and molecular self‐assembly. Such functional materials have promising applications in flexible electronic devices, such as electrochemical energy storage devices, sensors, biomimetic electronic skins, and optoelectronic devices. In this review, green solvents for cellulose, the dissolution–recombination process, molecular self‐assembly strategies, advanced applications, and future development prospects for high‐performance cellulose‐based functional materials with unique structures are presented.

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“…Thedenovo hydrogen-bonding pattern together with C À X···p halogen-bonding and C À X···X À Ci nteractions in this class of foldamers may enable the future design of novel functional supramolecular polymeric materials or nanomaterials.T he molecular architecture of this type of foldamer assembly was presented unambiguously at the atomic level, [19] and its ability to form 3D self-assembly supramolecular polymers was shown for the first time.…”

mentioning

confidence: 94%

Orthogonal Halogen‐Bonding‐Driven 3D Supramolecular Assembly of Right‐Handed Synthetic Helical Peptides

et al. 2019

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Peptide-mediated self-assembly is ap revalent method for creating highly ordered supramolecular architectures.H erein, we report the first example of orthogonal CÀ X···XÀC/CÀX···p halogen bonding and hydrogen bonding driven crystalline architectures based on synthetic helical peptides bearing hybrids of l-sulfono-g-AApeptides and natural amino acids.T he combination of halogen bonding, intra-/intermolecular hydrogen bonding,a nd intermolecular hydrophobic interactions enabled novel 3D supramolecular assembly.The orthogonal halogen bonding in the supramolecular architecture exerts an ovel mechanism for the selfassembly of synthetic peptide foldamers and gives new insights into molecular recognition, supramolecular design, and rational design of biomimetic structures.

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Orthogonal Halogen‐Bonding‐Driven 3D Supramolecular Assembly of Right‐Handed Synthetic Helical Peptides

Cited by 40 publications

References 75 publications

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

Molecular‐Scale Design of Cellulose‐Based Functional Materials for Flexible Electronic Devices

Orthogonal Halogen‐Bonding‐Driven 3D Supramolecular Assembly of Right‐Handed Synthetic Helical Peptides

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