Orthogonal Halogen‐Bonding‐Driven 3D Supramolecular Assembly of Right‐Handed Synthetic Helical Peptides

Abstract

Peptide-mediated self-assembly is ap revalent method for creating highly ordered supramolecular architectures.H erein, we report the first example of orthogonal CÀ X···XÀC/CÀX···p halogen bonding and hydrogen bonding driven crystalline architectures based on synthetic helical peptides bearing hybrids of l-sulfono-g-AApeptides and natural amino acids.T he combination of halogen bonding, intra-/intermolecular hydrogen bonding,a nd intermolecular hydrophobic interactions enabled novel 3D supramolecular assembly.The orthogonal halogen bonding in the supramolecular architecture exerts an ovel mechanism for the selfassembly of synthetic peptide foldamers and gives new insights into molecular recognition, supramolecular design, and rational design of biomimetic structures.

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