Orosomucoid and Haptoglobin Excretion in Rat Glomerulonephritis and Tubulonephritis

Abstract

Haptoglobin and orosomucoid were detected and measured in concentrated normal rat urine by radial immunodiffusion. Normal haptoglobin clearance was 33 nl/min (190 nl/ min/kg) and normal orosomucoid clearance 146 nl/min (840 nl/ min/kg). During nephrotoxic serum glomerulonephritis both glycoproteins increased considerably in urine in two phases; in serum, after an early peak, haptoglobin returned to the normal level and orosomucoid fell below the normal value. During mercuric chloride tubulonephritis, an early sharp peak of both glycoproteins was observed chiefly in urine but also in serum.

The Protein-Bound Carbohydrates of Seromucoid from Normal Human Serum

“…The amounts and types of seromucoids elevated, however, may vary in tissue destruction, proliferation or inflammation (1). Also, these levels would be affected by glomerular filtration and tubular reabsorption (14) and would, therefore, be altered in renal conditions. The seromucoid levels would be the net result of their synthesis in liver and their removal from blood into urine.…”