Oropharyngeal <scp>C</scp>andida colonization in human immunodeficiency virus infected patients

Li, Xiaoxu; Lei, Lei; Tan, Debao; Jiang, Lu; Zeng, Xin; Dan, Hongxia; Liao, Ga; Chen, Qianming

doi:10.1111/apm.12006

Cited by 17 publications

(16 citation statements)

References 124 publications

(322 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have shown a high prevalence of oral Candida carriage in HIV-infected individuals [5,6,[8][9][10], and this can vary according to sampling method and geographical location [5,8,9]. By using oral rinse for yeast isolation, other Brazilian surveys detected oropharyngeal Candida carriage in approximately 60% to 70% of HIV-infected individuals [6,8].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, this is by far the most prevalent commensal and pathogenic of the Candida species [3,5,6,[8][9][10]17,35]. However, increasing rates of colonization and even infections with other species of Candida in HIV-infected individuals have been observed elsewhere [2][3][4]8].…”

Section: Discussionmentioning

confidence: 99%

“…In individuals infected with human immunodeficiency virus (HIV), the prevalence of asymptomatic colonization of oral mucous is higher, approaching 80% [3][4][5][6][7][8][9][10][11]. Importantly, colonization of skin and mucous membranes with Candida species is an important risk factor that predisposes to candidiasis [12], whose clinical manifestations range from mucosal to life-threatening disseminated infections.…”

Section: Introductionmentioning

confidence: 99%

“…in these individuals have been attributed to progressive HIV-induced T-cell immunodeficiency [9]. On the other hand, as opportunistic pathogens, Candida spp.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oral Candida colonization in HIV-infected patients in Londrina-PR, Brazil: antifungal susceptibility and virulence factors

Paula

Morey

Santos

et al. 2015

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Host colonization by Candida species is an important predisposing factor to candidiasis, which seems to be more frequent in human immunodeficiency virus (HIV)-infected patients. Knowledge about the distribution, antifungal susceptibility, and virulence of oral Candida isolates is important for effective management of candidiasis. Methodology: Oral rinses were collected from 242 HIV-infected patients without clinical evidence of candidiasis seen at the AIDS referral center in Londrina, Brazil. Species were identified by standard phenotypic and molecular methods, and characterized in vitro according to antifungal susceptibility, cell surface hydrophobicity, biofilm formation, and enzyme activities. Results: Oral Candida colonization was detected in 50.4% of patients and combined use of antiretroviral therapy and protease inhibitor had a protective effect against colonization. Candida albicans (75.2%) was the most prevalent species. A high proportion of Candida spp. (39.9%) showed decreased susceptibility to fluconazole. Five isolates were resistant to nystatin. Protease and phospholipase activities were detected in 100% and 36.8% of isolates, respectively. Most isolates displayed a hydrophobic property that was associated with biofilm formation ability. Conclusions: A significant number of oral Candida species exhibiting decreased susceptibility to fluconazole were isolated from colonized HIV-infected individuals. Furthermore, all isolates expressed potential virulence attributes in vitro. Given the high incidence and severity of fungal infections in HIV-infected individuals, the results of this study reinforce the importance of antifungal susceptibility testing, which contributes to therapeutic strategies and highlights the need for continuous surveillance of Candida colonization in this population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…in these individuals have been attributed to progressive HIV-induced T-cell immunodeficiency [9]. On the other hand, as opportunistic pathogens, Candida spp.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oral Candida colonization in HIV-infected patients in Londrina-PR, Brazil: antifungal susceptibility and virulence factors

Paula

Morey

Santos

et al. 2015

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Varios autores en diferentes países han estudiado la colonización oral por Candida spp., en individuos infectados por el VIH (2,7,8). En Colombia se han publicado tres artículos relacionados con Candida spp., en la cavidad oral de pacientes VIH/sida (9-11), pero solo uno de ellos fue sobre colonización (9).…”

Section: Introductionunclassified

Candida en la cavidad oral de pacientes con VIH en Cali, Colombia: determinación de especies y sensibilidad al fluconazol

Castro

Álvarez

Martínez

2015

iatreia

View full text Add to dashboard Cite

Introducción: Candida albicans es la levadura aislada con mayor frecuencia de la cavidad oral de individuos VIH positivos. El uso del fluconazol ha incrementado el aislamiento de especies de Candida diferentes de C. albicans resistentes o con sensibilidad disminuida a este antimicótico.Objetivo: establecer, en individuos VIH positivos de un hospital de la ciudad de Cali, las especies de Candida de la cavidad oral, su densidad poblacional y la sensibilidad al fluconazol de aquellas diferentes de C. albicans.Materiales y métodos: las muestras se sembraron en CHROMagar Candida y se hizo el recuento de unidades formadoras de colonias (UFC); se identificaron las levaduras con el API 20C Aux y se hicieron las pruebas de sensibilidad al fluconazol con el Etest.Resultados: se estudiaron 230 pacientes y hubo 202 aislamientos: 106 fueron únicos y 96, mixtos. C. albicans fue la especie más frecuente, seguida por C. dubliniensis y C. glabrata. Las especies diferentes de C. albicans predominaron en los recuentos menores de 400 UFC/mL. El estudio de sensibilidad al fluconazol de las especies diferentes de C. albicans mostró que 14 (40 %) fueron sensibles dosis-dependientes y 7 (20 %), resistentes.Conclusión: en la población estudiada, la cavidad oral está colonizada por aislamientos no salvajes, lo que representa un riesgo para el desarrollo de candidiasis orofaríngea resistente al tratamiento con fluconazol.

show abstract

Dermatoses of the Oral Cavity and Lips

Scully¹

2016

Rook's Textbook of Dermatology, Ninth Edition

View full text Add to dashboard Cite

Oral and labial lesions are usually the result of local disease but may be the early signs of systemic disease, including dermatological disorders, and in some instances may cause the main symptoms. This chapter mainly discusses disorders of the periodontal and mucosal tissues that may be related to skin disease and that may present at a dermatology clinic. It should be borne in mind that the professionals most competent in diagnosing and treating oral diseases are those with formal dental training and who are therefore in a position to understand the full complexities of the region. This chapter is divided into a brief discussion of the biology of the mouth, an overview of the more common signs and symptoms affecting specific oral tissues, discussion of the disorders of the oral mucosa of most relevance to dermatology and a tabulated review of oral manifestations of systemic diseases. Only the more classic oral lesions are illustrated. For reasons of space restrictions, diseases affecting the teeth, salivary glands, jaws or temporomandibular joints are not discussed in any depth.

show abstract

Oropharyngeal Candida colonization in human immunodeficiency virus infected patients

Cited by 17 publications

References 124 publications

Oral Candida colonization in HIV-infected patients in Londrina-PR, Brazil: antifungal susceptibility and virulence factors

Oral Candida colonization in HIV-infected patients in Londrina-PR, Brazil: antifungal susceptibility and virulence factors

Candida en la cavidad oral de pacientes con VIH en Cali, Colombia: determinación de especies y sensibilidad al fluconazol

Dermatoses of the Oral Cavity and Lips

Contact Info

Product

Resources

About