Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber

Salzman, Gary; Pyszczynski, Dennis R.

doi:10.1016/0091-6749(88)90911-6

Cited by 111 publications

(34 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…87 In retrospect, a similar explanation might account for the results of Bronchodilators: -agonists and anticholinergic the Salzman and Pyszczynski study carried out about aerosols 12 years ago. 102 These authors compared BDP 800 g BID administered by MDI alone with administration Johnson et al showed that 3.3 m MMAD salbutamol of the same nominal dose via an Aerochamber aerosols provide greater bronchodilatation in mildadministered to systemic steroid-dependent patients. moderate stable asthmatics than 7.7 m aerosols.…”

Section: 69-71mentioning

confidence: 97%

Pressurized Metered Dose Inhalers and Add-on Devices

Terzano

2001

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

Section: 69-71mentioning

confidence: 97%

Pressurized Metered Dose Inhalers and Add-on Devices

Terzano

2001

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

“…11,31 The use of BDP inhalers has been associated with oropharyngeal and esophageal candidiasis, 42,43 but oral delivery of BDP did not result in an increased incidence of fungal or bacterial colonization or infections after HCT. 11,31 Metabolites of BDP are systemically bioavailable, resulting in decreased adrenal responsiveness over time of drug exposure.…”

Section: Discussionmentioning

confidence: 99%

A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease

Hockenbery

Cruickshank

Rodell

et al. 2007

Blood

110

View full text Add to dashboard Cite

We tested the hypothesis that oral beclomethasone dipropionate (BDP) would control gastrointestinal graft-versus-host disease (GVHD) in patients with anorexia, vomiting, and diarrhea. Patients were randomized to prednisone for 10 days and either oral BDP 8 mg/d (n ‫؍‬ 62) or placebo (n ‫؍‬ 67) tablets for 50 days. At study day 10, prednisone was rapidly tapered while continuing study drug. On an intentto-treat basis, the risk of GVHD-treatment failure was reduced for the BDP group at study day 50 (hazard ratio [

show abstract

“…Расширенной колонизации слизистых зева способствуют некоторые экзогенные и эндогенные факторы -сахарный диабет, онкологические забо-левания, иммуносупрессия, в т. ч. связанная с прие-мом глюкокортикостероидов (ГКС), прием антибак-териальных препаратов [5]. В немногочисленных исследованиях, касающихся изучения грибкового пейзажа зева у больных бронхиальной астмой (БА), применяющих ингаляционные ГКС (иГКС), данные о встречаемости орофарингеального кандидоза ко-леблются в широких пределах (1-77 %), вероятно, из-за метода, который использовался для обнаружения возбудителя [1][2][3][4]. Показано, что увеличению оро-фарингеальной колонизации Candida способствует…”

Section: оригинальные исследованияunclassified

“…Необходимо отме-тить, что за последнее десятилетие происходило ин-тенсивное исследование факторов вирулентности дрожжеподобных грибов Candida в патогенезе кан-дидозов и висцеральных микозов [2,3], основное внимание при этом уделяется таким детерминантам вирулентности, как внутриклеточные системы, обеспечивающие синтез секретируемых гидролити-ческих энзимов грибковой клеткой.…”

Section: резюмеunclassified

Virulent Properties of Genus Candida in Patients With Persistent Bronchial Asthma and Long-Term Treatment With Inhaled Steroids

Решетникова¹,

Тюрин²,

Glushko³

et al. 2014

Pulʹmonologiâ (Mosk.)

View full text Add to dashboard Cite

Вирулентные свойства грибов рода SummaryAim. The aim of this study was to investigate virulent properties of the genus Candida spp. in patients with persistent bronchial asthma and long-term treatment with inhaled steroids. Methods. In this study, virulent properties of the genus Candida spp. were investigated in oropharyngeal smears of 30 patients with persistent asthma treated with moderate-to-high dose inhaled corticosteroids (ICS) for at least 1 year. A control group included 15 steroid-naive asthmatic patients. Fungi were identified by conventional methods (morphology, presence of germination tubes, chlamydospores, fermentation of carbohydrates). Sensitivity to antibiotics was determined by disk method on the Saburo agar medium. Adhesion was assessed in a model with nitrocellulose film and immobilized hemoglobin. Proteinase activity was measured by the ELISA method in supernatant at two pH values: acidic (pH = 4.5) or weakly alkaline (pH = 7.8). CD cell leukocyte receptor proteolysis was evaluated by the cytofluorometrics method.Results. An incidence of fungal colonization of the pharynx in ICS-treated patients with bronchial asthma was 76.7 %. Most strains were highly virulent as they had significantly higher adhesive and enzymatic activity and multi-drug resistance to antifungals compared to control group. Conclusion. The ability of these strains to secrete proteolytic enzymes against CD4 + T-lymphocyte surface receptors could provide an additional immunomodulatory mechanism in Candida albicans invasion.

show abstract

Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber

Cited by 111 publications

References 21 publications

Pressurized Metered Dose Inhalers and Add-on Devices

Pressurized Metered Dose Inhalers and Add-on Devices

A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease

Virulent Properties of Genus Candida in Patients With Persistent Bronchial Asthma and Long-Term Treatment With Inhaled Steroids

Contact Info

Product

Resources

About