Orofacial granulomatosis with gingival onset

Mignogna, Michele Davide; Fedele, Stefano; Russo, Lucio Lo; Muzio, Lorenzo Lo

doi:10.1034/j.1600-051x.2001.028007692.x

Cited by 32 publications

(30 citation statements)

References 19 publications

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“…The association of CD with orofacial granulomatosis (OFG) is well recognized (3-6) but isolated gingival hyperplasia is not usual (7,8). Although our patient later developed the characteristic edema of the lips and, in that setting, could be classified within the spectrum of "typical" OFG, the sign that initially appeared was unspecific and characterized by swelling of the gums.…”

Section: Discussionmentioning

confidence: 61%

Gingival Hyperplasia as a First Manifestation of Crohn's Disease

et al. 2005

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Section: Discussionmentioning

confidence: 61%

Gingival Hyperplasia as a First Manifestation of Crohn's Disease

et al. 2005

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“…It varies in color from normal to salmon pink to red. [15]Tongue: Lateral aspects of the dorsum of the tongue are usually fissured.Facial palsy: A lower motor neuron palsy of facial nerve may rarely arise in OFG. [16]…”

Section: Discussionmentioning

confidence: 99%

Orofacial granulomatosis: A case report with review of literature

Rana

2012

J Indian Soc Periodontol

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Orofacial granulomatosis (OFG) encompasses conditions characterized by non-necrotizing granulomatous inflammation of the oral and maxillofacial region that present clinically as labial enlargement, perioral and/or mucosal swelling, oral ulcerations, and gingivitis. The unifying term “OFG” has been introduced to integrate the spectrum of various disorders, including Melkersson-Rosenthal syndrome and granulomatous cheilitis (which is sometimes considered to be a monosymptomatic form of Melkersson-Rosenthal syndrome), and has been shown to be associated with Crohn's disease, sarcoidosis, and infectious diseases such as tuberculosis. Although various etiological agents such as food substances, food additives, dental materials, and various microbiological agents have been implicated in the disease process, its precise pathogenesis is yet to be elucidated. Delayed type of hypersensitivity reaction appears to play a significant role, although the exact antigen inducing the immunological reaction varies in individual patients. However, evidence for the role of genetic predisposition to the disease is sparse. The underlying immunological mechanism appears to show some similarities between OFG and Crohn's disease, emphasizing the need for more comparative studies of the two entities. The aim of this article is to report a case of OFG, along with a detailed literature review of the facts and variations associated with its nomenclature, clinical presentation, and etiology. It also projects the challenges that a professional has to face in the diagnosis and treatment planning of such cases.

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“…Tuberculosis should be ruled out by acid fast bacillus staining and chest radiographs. 10%-37% of patients with OFG have been found to have Crohn's disease and oral lesions may precede the intestinal involvement (8). Hence, endoscopy and colorectal biopsy are justified when signs and symptoms of gastrointestinal disturbance is observed.…”

Section: Case Reportmentioning

confidence: 99%

Orofacial Granulomatosis - A Rare Case Report with Review of Literature

Reddy¹,

Rakesh²,

Ramadoss³

et al. 2010

J Clin Exp Dent

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The term orofacial granulomatosis (OFG) is a descriptive term used for granulomatous disorders affecting the face and oral cavity, which can occur for a variety of reasons resulting in significant morbidity. It is characterised by persistent swelling that may involve one or both the lips and /or recurrent ulcers and a variety of other orofacial features. Medical history is very important in the diagnosis of OFG as medical condition like Crohn's disease can also present an extra intestinal manifestation of OFG. Exclusion of other entities like sarcoidosis, mycobacterial infections, foreign body reactions and biopsy helps to establish a correct diagnosis. Herein we report a case of OFG in a 55 year old female patient with review of literature.

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Orofacial granulomatosis with gingival onset

Abstract: Thus, when none of the common causes of gingival enlargement can be detected, OFG diagnosis should be suspected.

Cited by 32 publications

References 19 publications

Gingival Hyperplasia as a First Manifestation of Crohn's Disease

Gingival Hyperplasia as a First Manifestation of Crohn's Disease

Orofacial granulomatosis: A case report with review of literature

Orofacial Granulomatosis - A Rare Case Report with Review of Literature

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