Gingival Hyperplasia as a First Manifestation of Crohn's Disease

Mergulhão, Paulo; Magro, Fernando; Pereira, Pedro; Correia, Raquel; Lopes, José Manuel; Magalhães, João; Dias, J.; Carneiro, Fátima; Tavarela-Veloso, Fernando

doi:10.1007/s10620-005-2965-2

Cited by 11 publications

(6 citation statements)

References 16 publications

(13 reference statements)

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“…They may appear before or after the onset of gastrointestinal symptoms 6,7. A number of characteristic oral lesions have been described in CD patients, including lip swelling, buccal mucosal swelling or cobblestoning, deep linear ulceration, mucosal tags, and gingival hyperplasia or mucogingivitis 7–9. The present clinical case documents the efficacy of infliximab in the treatment of oral CD.…”

supporting

confidence: 55%

“…Oral lesions in patients with CD have not been correlated with the severity or extent of intestinal involvement. They may appear before or after the onset of gastrointestinal symptoms 6,7. A number of characteristic oral lesions have been described in CD patients, including lip swelling, buccal mucosal swelling or cobblestoning, deep linear ulceration, mucosal tags, and gingival hyperplasia or mucogingivitis 7–9.…”

mentioning

confidence: 99%

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Successful infliximab therapy for oral Crohnʼs disease

Cardoso¹,

Nunes²,

Carneiro

et al. 2006

Inflammatory Bowel Diseases

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supporting

confidence: 55%

mentioning

confidence: 99%

Successful infliximab therapy for oral Crohnʼs disease

Cardoso¹,

Nunes²,

Carneiro

et al. 2006

Inflammatory Bowel Diseases

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“…Oral manifestations can also be caused by IBD‐induced malabsorption. Common oral signs and symptoms in patients with CD include pyostomatis vegetans, gingival hyperplasia, papillomatosis of the oral mucosa, vesicular eruptions such as in pemphigus vegetans, periodontitis, and caries (Sundh & Emilson 1989, Mergulhao et al 2005, Ruiz‐Roca et al 2005, Brito et al 2008). Different gingival and mucosal lesions have been reported in association with IBD including hypertrophy and swelling of lips, gingival hyperplasia, resembling epulis fissuratum, cobblestone appearance of the oral mucosa and palate, presence of vesicles, erosions, ulcers, aphthous‐like ulcerations, polypoid “taglike” lesions, and areas of necrosis (“snail‐track” lesions) (Ojha 2007).…”

Section: Extra‐intestinal Manifestations Of Ibdmentioning

confidence: 99%

What can we learn about biofilm/host interactions from the study of inflammatory bowel disease

Indriolo

Greco

Ravelli

et al. 2011

J Clinic Periodontology

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Objectives: The aim of this review was to evaluate possible common pathogenic pathways and risk factors in inflammatory bowel disease (IBD) and periodontitis. Materials and Methods: A MEDLINE-PubMed research was conducted. Results: The pathogenesis of both diseases is multi-factorial leading to a substantial defect of the mucosal barrier, deregulation of the immune response and chronic inflammation of the mucosa. Environmental factors, particularly bacteria, are key factors in the pathogenesis of both diseases. Genetic predisposition is a key factor in the IBD pathogenesis, while a clear role of genetics in the pathogenesis of periodontitis is still unclear. The immune response in IBD is mediated by T lymphocytes as a consequence of a genetic trait associated with T-cell deregulation. On the other hand, in periodontitis plasma cells and lymphocytes are the predominant cells in the chronic inflammatory lesion, with the presence of B cells being proportionally larger than T cells. Conclusion: IBD and periodontitis share several factors in their aetiology and pathogenesis, although they also have distinct characteristics.

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“…3 Numerous studies have also shown that oral lesions, especially in children, represent the initial manifestation of Crohn's disease and may precede gastrointestinal symptoms by months to years. [4][5][6][7] Oral manifestations of Crohn's disease can be divided into two categories: specific and nonspecific manifestations. 8 Nonspecific oral manifestations include aphthae, cheilitis angularis, lip fissures, fistulas, and gingival hyperplasia, which can occur in a variety of diseases.…”

Section: Discussionmentioning

confidence: 99%