“…1,2,3 Patients with this syndrome exhibit cognitive impairment as well as bone growth disorders and generalized muscle hypotonia. 4,5 Moreover, oral health problems, such as inadequate oral hygiene, periodontal disease, caries, malocclusion, and tooth loss, are more prevalent in this group of individuals than in the general population. 6,7,8,9 Malocclusion, in particular, exerts a considerable negative impact on the quality of life, causing problems related to the performance of daily activities, such as speech, swallowing, and chewing, and discrimination based on physical appearance.…”