Orofacial amyloidosis—unusual ­presentation of a rare condition: A case report

Abstract

Orofacial amyloidosis is an extremely rare and generally a benign condition. In contrast to systemic amyloidosis, other organs are not involved; however, extensive investigations are recommended to intercept any systemic involvement. Diagnosis is confirmed by histological examination and Congo red staining. This condition does not have a known etiology, and hence no general consensus exists regarding its management. We are presenting a case of a 65-year-old female patient with orofacial amyloidosis having ocular and extensive oral involvement.

Dysphagia due to macroglossia in a patient with amyloidosis associated with multiple myeloma: A case report

“…Diagnosis of amyloidosis is usually made associating the clinical features with histopathological exam, which reveal the presence of acellular eosinophilic deposits. These hyaline deposits typically show a perivascular distribution and they are positive for the Congo red staining and apple‐green birefringent under polarized light …”

“…These hyaline deposits typically show a perivascular distribution and they are positive for the Congo red staining and apple-green birefringent under polarized light. 1,[5][6][7] The aim of this report is to describe a clinical case of an elderly patient with dysphagia related to macroglossia and caused by primary amyloidosis associated with multiple myeloma. In this case, the organs predominantly involved were tongue, leading to macroglossia causing difficulty in swallowing.…”