Orodispersible Tablets of Carbamazepine Prepared by Direct Compression Method Using 3² Full Factorial Design

Abstract

Orodispersible tablets of carbamazepine were prepared with a view to enhance patient compliance by direct compression method using 3² full factorial design. Crospovidone (2-10% w/w) was used as superdisintegrant and microcrystallinecellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10 s); the formulation containing 2% w/w crospovidone and 30%w/w microcrystallinecellulose was found to be promising and tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40º/75 % RH for 3 w) and drug-excipient interaction. This formulation showed four-fold faster drug release (t 25% ) compared to the conventional commercial tablet formulation. Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05).

Formulation and evaluation of microsphere based oro dispersible tablets of itopride hcl

“…In vitro dispersion time was measured by dropping a tablet without disc in a measuring cylinder containing 10 ml of phosphate buffer pH 6.8 (simulated saliva fluid and time required for complete dispersion of a tablet was measured. In vitro disintegration test was carried out using USP XXIV tablet disintegration test apparatus (Pharma Test, Germany) [26]. The time for disintegration of ODTs is generally less than one min and actual disintegration time that patient can experience ranges from 5–30 seconds.…”

Design, Development and Formulation of Orodispersible Tablets of a Model Drug Using Response Surface Methodology

“…Therefore, Addition of different Superdisintegrants were added to decrease the disintegration time thereby increasing the bioavailability and wetting agent was employed to enhance its solubility [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Formulation and Development of Taste Masked Orally Disintegrating Tablets of Perindopril Erbumine by Direct Compression Method

“…A 3 2 randomized full factorial design was adopted to optimize the variables. In this design 2 factors were evaluated, each at 3 levels, and experimental trials were performed at all 9 possible combinations [15][16][17][18]. Layout of full factorial design is shown in table 4.…”