ORO-Facial granulomatosis: a possible allergic basis

Patton, Douglas; Ferguson, M.M.; Forsyth, A.; Ja, James

doi:10.1016/0266-4356(85)90038-5

Cited by 81 publications

(57 citation statements)

References 17 publications

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“…4 It is probable that OFG represent a spectrum of disease that ranges from localized granulomatous inflammation of the lips (granulomatous cheilitis, Miescher cheilitis), through orofacial swelling with mucosal ulceration to disease with neurologic deficit and lingual fissuring (Melkersson-Rosenthal syndrome). [5][6][7][8][9] The increasing number of reports of small numbers of patients with OFG may suggest that the prevalence of this disorder may be rising, and certainly clinical experience in the current study center would indicate that this change in prevalence is real. There remain, however, few reports of substantial numbers of patients attending a single center to allow clear descriptions of the clinical features, long-term behavior, and likely successful therapeutic regimens of OFG.…”

mentioning

confidence: 99%

Orofacial granulomatosis: Clinical features and long-term outcome of therapy

Johani

Moles

Hodgson

et al. 2010

Journal of the American Academy of Dermatology

101

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mentioning

confidence: 99%

Orofacial granulomatosis: Clinical features and long-term outcome of therapy

Johani

Moles

Hodgson

et al. 2010

Journal of the American Academy of Dermatology

101

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“…A large retrospective study of patch test results demonstrated positive patch testing in 30 % of patients with OFG [5]. The most common allergens involved benzoic acid (found in food preservatives), fragrance, and cinnamon [26,27,29]. An 8-week study of a cinnamon-and benzoate-free diet demonstrated significantly decreased oral inflammation in OFG patients [28].…”

Section: Orofacial Granulomatosismentioning

confidence: 96%

Mucosal Lesions in an Allergy Practice

Kohorst

Bruce

Torgerson

2016

Curr Allergy Asthma Rep

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The diagnosis and treatment of mucosal disease with an allergic pathogenesis are challenging. Oral allergy is often a hypersensitivity reaction with variable symptoms and physical exam findings. Clinical diagnosis requires a history of prior allergen exposure, a delay from exposure to clinical findings, and improvement following allergen removal. The past decades have seen great contributions to the field of oral allergy. The aim of this review is to provide an approach to the diagnosis and treatment of oral dermatologic disease with a focus on diseases with an investigated allergic pathogenesis.

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“…Different theories have been suggested, involving infection, genetic predisposition and allergy. [5] Suggested underlying mechanisms include lymphocytic infiltration due to the chronic antigenic stimulation, cytokine production resulting in formation of granulomas and cell-mediated hypersensitivity reaction with associated lymphatic blockage caused by granulomas, leading to diffuse swelling by the lymphedema. [6] Various systemic diseases are related with granulomatous cheilitis including mycobacterial infection, sarcoidosis, Crohn's disease, Wegener's granulomatosis, histoplasmosis and amyloidosis rosacea; medications such as ACE inhibitors and calcium channel blockers; atopic reaction to a wide variety of allergens and hereditary diseases such as C1 esterase deficiency.…”

Section: Introductionmentioning

confidence: 99%

Granulomatous chelitis of the upper lip in a child

Khan

Agrawal

2016

Int J of Biomed & Adv Res

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Granulomatous cheilitis is a chronic granulomatous inflammatory condition involving the lips with a multifactorial etiology. The difficulty in treatment of granulomatous cheilitis is reflected in various treatments that have been tried and the lack of consensus regarding the preferred treatment. Combined therapy of intralesional corticosteroid and clofazimine or dapsone is one of the most commonly used treatments for the condition. Other treatment options are prednisone,antibiotics such as metronidozole,tetracycline hydroxychloroquine, sulfasalazine, antihistamines, macrolides, thalidomide and infliximab. However, therapeutic responses of patients with granulomatous cheilitis are often unpredictable and spontaneous recurrences are not uncommon .Therefore, an oral physician must carefully proceed in order to develop an accurate treatment planning. Management considerations for these patients depend upon the results of the investigations, patient's esthetic considerations and severity of the condition. A case of a nine year old child with the granulomatous cheilitis of upper lip who showed an excellent response to intalesional steroids, metronidazole and doxycycline, a combined therapeutic regimen is reported here.

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ORO-Facial granulomatosis: a possible allergic basis

Cited by 81 publications

References 17 publications

Orofacial granulomatosis: Clinical features and long-term outcome of therapy

Orofacial granulomatosis: Clinical features and long-term outcome of therapy

Mucosal Lesions in an Allergy Practice

Granulomatous chelitis of the upper lip in a child

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