1982
DOI: 10.1016/0003-9861(82)90148-5
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Ornithine synthesis from glutamate in rat small intestinal mucosa

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1983
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Cited by 29 publications
(14 citation statements)
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“…In the present study, the plant protein OAT was expressed in E. coli, partially purified and its activity was estimated in presence of different amino acids. In earlier studies with rat liver and kidney, PLP stimulated ornithine synthesis and OAT activity [9]. Omission of PLP reduced the specific activity of OAT by 60% in the present study, thus confirming the earlier studies carried in animals.…”
Section: Discussionsupporting
confidence: 95%
“…In the present study, the plant protein OAT was expressed in E. coli, partially purified and its activity was estimated in presence of different amino acids. In earlier studies with rat liver and kidney, PLP stimulated ornithine synthesis and OAT activity [9]. Omission of PLP reduced the specific activity of OAT by 60% in the present study, thus confirming the earlier studies carried in animals.…”
Section: Discussionsupporting
confidence: 95%
“…Although enterocytes are equipped with enzymatic machinery for ornithine production from glutamate [14], the production of ornithine from L -[U- 14 C] glutamate was found to be very low, as previously reported in intestinal absorptive cells, the main precursor of ornithine being arginine [12]. This is in accordance with a previous study [34]showing that gut ornithine and arginine production is not altered by dietary glutamate.…”
Section: Discussionsupporting
confidence: 80%
“…Both glutamine and glutamate are metabolized in the intestine [8, 9]. Glutamine is considered as a fuel in intestinal absorptive cells and leads to the production of various metabolites including glutamate, ammonia, alanine [10, 11], aspartate [12], ornithine, citrulline and proline [13, 14, 15], glutathione [16, 17]and N-acetyl-glutamate [18]. Convincing evidence has been presented in favor of a complete metabolism of glutamate after a meal by the splanchnic bed [19, 20, 21].…”
Section: Introductionmentioning
confidence: 99%
“…Windmueller and Spaeth (1 488 1) demonstrated that some of the ghtamine that is metabolized by the small intestine is converted to citmlline. The enzymology of this process has been clarified by Jones and her associates (Henslee andJones 1982: Wakabayashi andJones 1983). Glutamine is converted to glutamate by glutaminase, followed by phosphorylation to yglratarnyl phosphate, reduction to y-glutamyl semialdehyde (both steps probably catalyzed by pyrroline-5-carboxylate synthase), and transamination by omithine aminotransferase to omithine.…”
Section: Gitrulline and Argininementioning
confidence: 98%