Ornithine induced retinopathy in rat: 2. Process of disappearance of choriocapillaris

Maeda, Hidemi; Takeuchi, Masamitsu; Takahashi, Kanji; Itagaki, T; Ohkuma, H; Uyama, M

doi:10.1016/s0021-5155(97)90197-0

Cited by 1 publication

(3 citation statements)

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“…At the late stage, the photoreceptor cells and choriocapillaris degenerate and finally disappear. These histopathological changes were similar for intravitreal doses of 0.25-1.0 M ornithine in rats and monkeys [13][14][15][16].…”

Section: Discussionmentioning

confidence: 75%

“…The selective damage of the retinal pigment epithelium (RPE) is well known in GA patients [20,21] and in animals following intravitreal injection of ornithine [12][13][14][15][16][22][23][24]. In the experiment with rats and monkeys, the RPE showed marked swelling following the ornithine injection while the outer segments, the photoreceptor cells and other retinal cells remained normal at the early stage.…”

Section: Discussionmentioning

confidence: 99%

“…Accompanying the biochemical, metabolic and genetic studies of GA, experimental models of GA were developed in animals, and investigators focused on the morphological changes in the pigment epithelial cells, choriocapillaris [12][13][14][15][16] and the c-wave of the ERG [17]. In these studies, the ERG changes were described only as subnormal or undetectable [2,3,9,10,18,19], and the changes were not described in any detail.…”

Section: Introductionmentioning

confidence: 99%

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Facilitatory and Neurotoxic Effects of Intravitreal Ornithine on the Electroretinographic Responses of Albino Rats

Mizota¹,

Sato²

2001

Ophthalmic Res

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The effect of an intravitreal injection of ornithine on the retina of rats was studied electroretinographically. Rats were injected intravitreally with 5 µl of 0.02, 0.25 and 0.5 M ornithine. Electroretinograms (ERGs) were recorded before, and 1, 3 and 9 days after the injection. High doses of ornithine (0.5 M) reduced while low doses (0.02 M) enhanced the ERG amplitudes. The implicit time of the a-wave was delayed at all concentrations after ornithine injection, which suggests that implicit times may be a more sensitive parameter of the ornithine effect. There were significant changes in the stimulus intensity necessary to obtain the one half of the maximum amplitude of the b-wave that may have been caused by damage of the photoreceptors and retinal pigment epithelium cells by ornithine. We conclude that the effect of ornithine on retinal function is dose dependent and can either enhance or depress the ERG amplitudes.

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Section: Discussionmentioning

confidence: 75%