Orlans HO, Hornby SJ, Bowler IC (2011) In vitro antibiotic susceptibility patterns of bacterial keratitis isolates in Oxford, UK: a 10-year review. Eye Jan 21 [Epub ahead of print] PMID 21252952

Corneal Culture and Antibiotic Susceptibility Results for Microbial Keratitis in the Mid-Atlantic Region of the United States, 2016 to 2020

“…Finally, assessment of antibiotic resistance using minimum inhibitory concentrations (MICs) used for systemic antibiotics may overestimate resistance as antibiotic concentrations achieved in corneal tissue using eye drops are typically far greater than systemic concentrations achieved by oral or parenteral routes. 43 The correlation between clinical ophthalmic response and MIC for coagulase-negative staphylococci and streptococci has been lower than for Pseudomonas and S. aureus . 44…”

“…Finally, assessment of antibiotic resistance using minimum inhibitory concentrations (MICs) used for systemic antibiotics may overestimate resistance as antibiotic concentrations achieved in corneal tissue using eye drops are typically far greater than systemic concentrations achieved by oral or parenteral routes. 43 The correlation between clinical ophthalmic response and MIC for coagulase-negative staphylococci and streptococci has been lower than for Pseudomonas and S. aureus. 44 As this study's primary purpose was to examine the distribution of microbial etiologies of culture-positive microbial keratitis, this analysis did not delve into details of cases where medical treatment failed and surgery was performed, which will be investigated in the future.…”