Effektivität antibiotischer Initialtherapie in der Behandlung der kontaktlinsenassoziierten bakteriellen Keratitis

Steger, Bernhard; Speicher, L.; Philipp, Wolfgang; Gasser, Thomas; Schmid, E.; Bechrakis, Nikolaos E.

doi:10.1007/s00347-013-2937-4

Cited by 1 publication

(2 citation statements)

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“…The ratio of gram-positive and gram-negative bacteria in our study was similar to geographically and socioeconomically comparable locations, such as Basel (Switzerland), Manchester (UK), New York (USA), and St. Louis (USA) [ 6 , 18 – 20 ]. In line with our results, Steger et al in Basel found a significantly higher ratio of gram-negative bacterial isolates in contact lens samples (71%) than in of conjunctival swabs of patients with bacterial keratitis (37%) [ 16 ]. This association between gram-negative bacterial infection and wearing contact lenses is well known, and possibly caused by biofilm formation [ 21 – 24 ].…”

Section: Discussionsupporting

confidence: 92%

“…In spite of difficulties comparing the bacterial spectrum because of the varying inclusion criteria [ 6 , 10 – 14 , 16 , 17 ], geographic variations in the bacterial spectrum in ocular surface-based isolates have been described [ 5 ]. The ratio of gram-positive and gram-negative bacteria in our study was similar to geographically and socioeconomically comparable locations, such as Basel (Switzerland), Manchester (UK), New York (USA), and St. Louis (USA) [ 6 , 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009–2019

Roth

Goerke

Holtmann

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Purpose Aim of this study was to evaluate the frequencies, trends, and antibiotic resistance of bacteria collected from ocular surface or contact lens material in a German tertiary referral center from 2009 to 2019. Methods Microbiological data from 2009 to 2019 was analyzed. Culture-dependent microbial identification and analysis of antibiotic sensitivity was completed by the Institute of Microbiology. Statistical analysis of age- and sex-specific differences as well as changes in the microbial spectrum and resistance over the study period was performed with GraphPad Prism 9.0 applying nonparametric tests (level of significance: p ≦ 0.05). Results A total of 6361 specimens were analyzed. Positivity rate was 18.6%. Sixty-three percent (n = 680) of the bacterial isolates were derived from ocular surface and 37% (n = 399) from contact lens material. The ratio of gram-negative bacteria was significantly higher in contact lens material. Multiresistant bacteria showed a significant increase with patient age (p < 0.0001). An overall increase in resistance to levofloxacin (p = 0.0239) was detected. Only 2.4% and 3.1% isolates were resistant to a combination of moxifloxacin and gentamicin, respectively, levofloxacin and gentamicin. Conclusions The reported bacterial spectrum is similar to comparable centers. Our data show that it should not be assumed that the newest classes of antibiotics have the best efficacy or lowest resistance levels. In suspected bacterial conjunctivitis, we propose using gentamicin as first-line therapy. In therapy refractive cases and in involvement of the cornea, we recommend a combination of gentamicin and ofloxacin or moxifloxacin. Overall, the evaluated organisms showed good sensitivity to the regularly used antibiotics.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009–2019

Roth

Goerke

Holtmann

et al. 2022

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

Effektivität antibiotischer Initialtherapie in der Behandlung der kontaktlinsenassoziierten bakteriellen Keratitis

Abstract: Empirical combined regimens remain an effective treatment of contact lens-related keratitis. Fluoroquinolones proved to be inadequate for monotherapy.

Cited by 1 publication

References 25 publications

Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009–2019

Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009–2019

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