“…The traditional method of classifying neurodegenerative diseases is based on the original clinicopathological concept, viz., a disease entity is a specific combination of clinical features and a distinctive neuropathology [40,45,59]. It was this principle, originally applied to small numbers of cases, that resulted in the first descriptions of Alzheimer's disease (AD) [1,60], Pick's disease (PiD) [116], dementia with Lewy bodies (DLB) [45,87], Creutzfeldt-Jakob disease (CJD) [32,75], and progressive supranuclear palsy (PSP) [128].…”