Origins of landmark encoding in the brain

Yoder, Ryan M.; Clark, Benjamin J.; Taube, Jeffrey S.

doi:10.1016/j.tins.2011.08.004

Cited by 131 publications

(124 citation statements)

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“…These neurons fire maximally at a particular head orientation relative to gravity, in a way analogous to rodent azimuth-tuned HD cells, whose preferred direction is anchored to visual landmarks 8,9 . The gravity-tuned cells didn’t appear to be tuned to head azimuth; however the tuning of HD cells is frequently suppressed during head-fixed rotation in rodents 10 .…”

Section: Resultsmentioning

confidence: 97%

“…We 7 have hypothesized that gravity provides a global allocentric reference for spatial orientation. Head direction (HD) cells form a “neuronal compass”, encoding head orientation in the horizontal plane 8 as well as head orientation relative to vertical, as shown recently in the dorsal presubiculum of bats 9 . Here we searched for gravity-tuned cells in the macaque anterior thalamus, where HD cells are found in rodents 8 .…”

Section: Introductionmentioning

confidence: 94%

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Gravity orientation tuning in macaque anterior thalamus

et al. 2016

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Gravity may provide a ubiquitous allocentric reference to the brain’s spatial orientation circuits. Here we describe neurons in the macaque anterior thalamus tuned to pitch and roll orientation relative to gravity, independent of visual landmarks. We show that individual cells exhibit two-dimensional tuning curves, with peak firing rates at a preferred vertical orientation. These results identify a thalamic pathway for gravity cues to influence perception, action and spatial cognition.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 94%

Gravity orientation tuning in macaque anterior thalamus

et al. 2016

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“…From external sensory signals, visual (landmark) information is the most potent source maintaining and updating activity of head-direction cells (Yoder et al, 2011a). The current hypothesis of how visual landmark cues control directional tuning suggests that the postsubiculum (Goodridge and Taube, 1997) and the retrosplenial cortex (Clark et al, 2010) might transfer visual landmark information to spatial signals within the limbic system (Yoder et al, 2011b).…”

Section: Integration Of Internal Idiothetic and External Sensory Signalsmentioning

confidence: 96%

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing

Tsanov

O’Mara

2015

Brain Research

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a b s t r a c tA major tool in understanding how information is processed in the brain is the analysis of neuronal output at each hierarchical level through which neurophysiological signals are propagated. Since the experimental brain operation performed on Henry Gustav Molaison (known as patient H.M.) in 1953, the hippocampal formation has gained special attention, resulting in a very large number of studies investigating signals processed by the hippocampal formation. One of the main information streams to the hippocampal formation, vital for episodic memory formation, arises from thalamo-hippocampal projections, as there is extensive connectivity between these structures. This connectivity is sometimes overlooked by theories of memory formation by the brain, in favour of theories with a strong corticohippocampal flavour. In this review, we attempt to address some of the complexity of the signals processed within the thalamo-hippocampal circuitry. To understand the signals encoded by the anterior thalamic nuclei in particular, we review key findings from electrophysiological, anatomical, behavioural and computational studies. We include recent findings elucidating the integration of different signal modalities by single thalamic neurons;we focus in particular on the propagation of two prominent signals: head directionality and theta rhythm. We conclude that thalamo-hippocampal processing provides a centrally important, substantive, and dynamic input modulating and moderating hippocampal spatial and mnemonic processing. This article is part of a Special Issue entitled SI: Brain and Memory.& 2014 Published by Elsevier B.V. IntroductionThe purpose of the present review is to dissect some of the complexity of the signals propagated from anterior thalamus to the hippocampal formation in order to try and understand the importance of this information processing for the coding properties of individual neurons in the hippocampus. "Anterior thalamus" includes the anterodorsal, anteroventral and dorsolateral thalamic nuclei, which form the thalamic component of the limbic system (the 'thalamic

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“…In the absence of external stationary input, errors from noise in the self-motion integration process accumulate, and place fields (and head direction tuning curves) would start to drift. However, in environments with salient cues, rapidly formed associations between cues and place cells enable stabilization of the firing fields, and previously formed maps can be recalled from session to session 10,[19][20][21]90 , possibly cued by landmark information conveyed through the dorsal presubiculum 92 . Nevertheless, there is also some support for the idea that place cells are formed by integration of salient sensory inputs, independently of movement.…”

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confidence: 99%