Origins of hydration lubrication

Ma, Liran; Gaisinskaya-Kipnis, Anastasia; Kampf, Nir; Klein, Jacob

doi:10.1038/ncomms7060

Cited by 297 publications

(324 citation statements)

References 30 publications

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“…[ 28 ] Second, shearing off whole adsorbed mucin macromolecules from either the PDMS or the steel surface may additionally contribute to the observed reduction in friction. [ 24 ] When coatings were built from partially or fully deglycosylated mucins, the friction coeffi cient was as high as without any mucin coating.…”

Section: Mucin Deglycosylation Results In Dehydrated and Poorly Lubrimentioning

confidence: 99%

Modulating Mucin Hydration and Lubrication by Deglycosylation and Polyethylene Glycol Binding

Crouzier

Boettcher

Geonnotti

et al. 2015

Adv Materials Inter

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glycoproteins, a family of high molecular weight and densely glycosylated biopolymers. Those mucins can act as an infection shield by trapping various viruses in the biopolymer matrix [ 1 ] and they reduce bacterial adhesion to surfaces. [ 2,3 ] Mucins also form highly hydrated and lubricative layers that protect the underlying epithelium from dehydration and shear stress that emerge during eye blinking or when swallowing food. Water typically accounts for up to 95% of the total mass in the mucus gel. [ 4,5 ] Shifts in the mucus water content correlate with substantial changes of the mucus barrier function [6][7][8] and result in important pathological disorders such as dry mouth [ 9 ] and dry eye. [ 10 ] Mucin-associated glycans contribute up to 80% of the molecular weight of mucins [ 11 ] and contain highly hydrated hydroxyl groups. Differences in the amount and composition of glycans from mucins extracted from pig stomachs and mucins from bovine submaxillary glands correlate with their capacity to adsorb water. [ 12 ] However, other properties such as protein composition also differ between these two mucin species, precluding the establishment of a defi nitive link between the presence of mucin glycans and hydration.Mucins, and other well-hydrated molecules such as zwitterionic polymers, polysaccharides, and polyelectrolytes are generally good boundary lubricants when adsorbed [ 13,14 ] or assembled in brush structures [15][16][17][18] on surfaces. Hence, mucin-associated glycans could also be essential for the lubricative function of mucus. In a related system, the mucin-like macromolecule lubricin showed a signifi cant decrease in lubricity when its associated glycans were removed. [ 19 ] Moreover, the lubricity of salivary fi lms, which contain mucins, has also been correlated with the total amount of glycosylation present in the fi lm. However, also here, the complexity of saliva composition precluded the identifi cation of the specifi c role of mucin glycosylation. [ 20 ] Hence, there is a need for a more defi ned experimental system to determine if mucin glycosylation is essential to the hydration and lubrication properties of mucins.This study explores the role of glycosylation in mucin hydration and lubricity, using mucin coatings as a simplifi ed model system. Such mucin coatings can reconstitute levels of surface hydration [ 21,22 ] and lubrication [23][24][25] similar to those found in native mucus. Our data show that the removal of mucin-bound glycans results in a signifi cant reduction in hydration and lubricity of the mucin-coated surface. We show that the hydration and lubricity of deglycosylated mucins can be partially A key property of mucin glycoproteins is their exceptional capacity to hydrate and lubricate surfaces. In vivo, mucins assemble into mucus hydrogels that cover the epithelium and protect it from dehydration and shear stress. A better understanding of the origin of these properties could lead to new treatment strategies for patients with poor mucus coverage, defective mucus produ...

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Section: Mucin Deglycosylation Results In Dehydrated and Poorly Lubrimentioning

confidence: 99%

Modulating Mucin Hydration and Lubrication by Deglycosylation and Polyethylene Glycol Binding

Crouzier

Boettcher

Geonnotti

et al. 2015

Adv Materials Inter

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“…We confirm the existence of highly conductive magnetic DWs by direct imaging with microwave impedance microscopy (MIM). MIM is a scanning probe technique that probes local conductivity by measuring tip-sample impedance at ~1 GHz (20)(21)(22): more conductive regions screen the microwave electric field better, resulting in a smaller tip-sample impedance. Working at high frequency eliminates the need of a back electrode and a complete current path, making MIM ideal for bulk insulating samples (23).…”

mentioning

confidence: 99%

Mobile metallic domain walls in an all-in-all-out magnetic insulator

Yue

Cui

Ueda

et al. 2015

Science

178

126

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Visualizing conducting domain walls When a metal undergoes a phase transition and becomes insulating, it sometimes also becomes magnetically ordered. It is possible that some metallicity survives along the boundaries of magnetic domains, the so-called domain walls, but the question is difficult to address directly in experiments. Ma et al. did just that by mapping out the conductance of the material Nd 2 Ir 2 O 7 in its low-temperature magnetic insulating phase, using microwave impedance microscopy. The magnetic domain walls showed up clearly in the images as regions of high conductance. Science , this issue p. 538

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“…This allowed the clear observation of different dissipation regimes, and enabled the isolation of frictional dissipation arising from the shear of the sub-nanometer hydration shells themselves, intrinsic to all hydration lubrication processes, from any system-dependent dissipation mechanisms, as shown in Fig. 5 [24]. The experiment suggested that frictional forces even in such simple systems can be dominated by rate-activated pathways.…”

Section: Liquid Superlubricitymentioning

confidence: 88%

New achievements in superlubricity from international workshop on superlubricity: fundamental and applications

2015

Friction

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Since the term "superlubricity" was put forward at the beginning of 1990s, it has become one of the hottest researches in tribology due to it being close linked to the energy problems. Recently, the International Workshop on "Superlubricity: Fundamental and Applications" was successfully held on 19-20 October 2015 in Beijing, which has attracted many researchers in this field. The recent scientific results in both solid superlubricity and liquid superlubricity have been presented according to these invited wonderful lectures and posters. In the communication, we gave an introduction to the Workshop on Superlubricity, and also summarized the new achievements of superlubricity during recent years according to these reports. Finally, the problems of superlubricity mechanism and the future development direction of superlubricity are discussed.

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Origins of hydration lubrication

Cited by 297 publications

References 30 publications

Modulating Mucin Hydration and Lubrication by Deglycosylation and Polyethylene Glycol Binding

Modulating Mucin Hydration and Lubrication by Deglycosylation and Polyethylene Glycol Binding

Mobile metallic domain walls in an all-in-all-out magnetic insulator

New achievements in superlubricity from international workshop on superlubricity: fundamental and applications

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