ORIGINAL ARTICLE: Serum Anti‐endometrial Antibodies in Infertile Women – Potential Risk Factor for Implantation Failure

Sarapik, Aili; Haller-Kikkatalo, Kadri; Utt, Meeme; Teesalu, Kaupo; Salumets, Andres; Uibo, Raivo

doi:10.1111/j.1600-0897.2010.00808.x

Cited by 34 publications

(33 citation statements)

References 34 publications

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“…HSPs are the major antigens and can induce a strong immune response [42]. Because there is a strong amino acid sequence homology between microbial and human HSPs, the induced immune response against microbial HSPs may incite an autoimmune inflammatory reaction in the host, culminating in tubal damage [42, 43]. …”

Section: Reproductive Autoimmune Failure In Womenmentioning

confidence: 99%

“…About 40%–60% of patients with endometriosis have elevated autoantibody titers when tested against a panel of autoantigens [47]. They often possess specific antiendometrial antibodies [43, 48, 49], but also AOA, antinuclear autoantibodies (ANA), smooth muscle autoantibodies (SMA), and antiphospholipid antibodies (APA) [23, 50, 51]. …”

Section: Reproductive Autoimmune Failure In Womenmentioning

confidence: 99%

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Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Haller-Kikkatalo

Salumets

Uibo

2012

Clinical and Developmental Immunology

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Female fertility can be affected by diseases or dysfunctions of reproductive tract, neuroendocrine system, and immune system. Reproductive autoimmune failure can be associated with overall activation of immune system or with immune system reactions specifically directed against ovarian antigens. Majority of the antiovarian autoantibodies are directed against β-subunit of follicle stimulating hormone (anti-FSH). This paper summarizes a current clinical classification of female infertility in the context of general activation of autoimmunity and antiovarian autoimmunity by describing serum anti-FSH. The presence of naturally occurring anti-FSH in healthy women will be discussed. In addition, the putative impairment of ovarian folliculogenesis in case of increased production of those antibodies in infertile women will be characterized.

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Section: Reproductive Autoimmune Failure In Womenmentioning

confidence: 99%

Section: Reproductive Autoimmune Failure In Womenmentioning

confidence: 99%

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Haller-Kikkatalo

Salumets

Uibo

2012

Clinical and Developmental Immunology

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“…Immunological abnormalities have been implicated in female reproductive failure, but whether these represent a cause or effect is unknown [1, 2]. According to our previous research, cellular and, particularly, humoral autoimmunologic perturbations are responsible for development of female infertility.…”

Section: Introductionmentioning

confidence: 99%

Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success

Sarapik

Velthut

Haller-Kikkatalo

et al. 2012

Clinical and Developmental Immunology

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Cytokines are key modulators of the immune system and also contribute to regulation of the ovarian cycle. In this study, Bender MedSystems FlowCytomix technology was used to analyze follicular cytokines (proinflammatory: IL-1β, IL-6, IL-18, IFN-γ, IFN-α, TNF-α, IL-12, and IL-23;, and anti-inflammatory: G-CSF), chemokines (MIP-1α, MIP-1β, MCP-1, RANTES, and IL-8), and other biomarkers (sAPO-1/Fas, CD44(v6)) in 153 women undergoing in vitro fertilization (IVF). Cytokine origin was studied by mRNA analysis of granulosa cells. Higher follicular MIP-1α and CD44(v6) were found to correlate with polycystic ovary syndrome, IL-23, INF-γ, and TNF-α with endometriosis, higher CD44(v6) but lower IL-β and INF-α correlated with tubal factor infertility, and lower levels of IL-18 and CD44(v6) characterized unexplained infertility. IL-12 positively correlated with oocyte fertilization and embryo development, while increased IL-18, IL-8, and MIP-1β were associated with successful IVF-induced pregnancy.

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“…[26][27][28] One recent finding is serum anti-endometrial antibodies in infertile women that might constitute a potential risk factor for implantation failure. 29 The inflammatory environment occurring in ectopic endometrium results in high tissue factor (TF) expression causing further inflammatory cytokine or chemokine production, process that probably causes a reduced fertility. 30 A recent study shows that antilaminin-111 autoantibodies may have a major pathogenic role on endometriosis-associated infertility.…”

Section: Endometriosis Infertility and The Immune Systemmentioning

confidence: 99%

Immunological Aspects of Endometriosis: An Update

Olovsson

2011

American J Rep Immunol

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Citation Olovsson M. Immunological Aspects of Endometriosis: An Update. Am J Reprod Immunol 2011; 66 (Suppl. 1): 101–104ProblemEndometriosis is a very complex disease that profoundly affects the quality of life of many women.Method of studyA review of the relationships between the female immune system and the occurrence and development of endometriosis.ResultsFunction and dysfunction of the female immune system plays important roles in the initiation and progression of the disease and its relation to infertility and cancer.ConclusionsOwing to obvious associations between endometriosis and the immune system, future treatment strategies might be based on immunological concepts and methods.

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ORIGINAL ARTICLE: Serum Anti‐endometrial Antibodies in Infertile Women – Potential Risk Factor for Implantation Failure

Abstract: Determination of the presence and spectra of AEA in patients with endometriosis and TFI undergoing IVF may be a useful marker to predict their pregnancy outcome.

Cited by 34 publications

References 34 publications

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success

Immunological Aspects of Endometriosis: An Update

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