Immunological Aspects of Endometriosis: An Update

Abstract

Citation Olovsson M. Immunological Aspects of Endometriosis: An Update. Am J Reprod Immunol 2011; 66 (Suppl. 1): 101–104ProblemEndometriosis is a very complex disease that profoundly affects the quality of life of many women.Method of studyA review of the relationships between the female immune system and the occurrence and development of endometriosis.ResultsFunction and dysfunction of the female immune system plays important roles in the initiation and progression of the disease and its relation to infertility and cancer.ConclusionsOwing to obvious associations between endometriosis and the immune system, future treatment strategies might be based on immunological concepts and methods.

Hexane extract of aged black garlic reduces cell proliferation and attenuates the expression of ICAM-1 and VCAM-1 in TNF-α-activated human endometrial stromal cells

“…In agreement with the results of previous studies, we also demonstrate that TNF-α stimulation promotes the activation of NF-κB and AP-1, critical regulators of cell proliferation and inflammatory responses in HESCs, suggesting that these transcription factors are key factors in the pathogenesis of endometriosis (3,14). The canonical pathway of NF-κB is activated in endometriotic lesions, and modulation of NF-κB activity and the consequent cell responses, including proliferation, inflammation and adhesion are important in the development of endometriosis (3,13,24,25).…”

“…The canonical pathway of NF-κB is activated in endometriotic lesions, and modulation of NF-κB activity and the consequent cell responses, including proliferation, inflammation and adhesion are important in the development of endometriosis (3,13,24,25). Thus, it is noteworthy that the present study demonstrated that HEABG significantly inhibits the TNF-α-induced activation of NF-κB and AP-1 in HESCs.…”

“…The immune system plays an important role in the development of endometriosis (2,3). Cell adhesion molecules, such as ICAM-1 and VCAM-1, play critical roles in various inflammatory and immunological functions, including cell-cell adhesion (4).…”

“…However, the stimuli promoting the attachment and outgrowth of endometrial cells in the peritoneal cavity have remained largely unknown. Among many factors suggested to be involved in the pathogenesis of endometriosis, immunological and inflammatory responses have been suggested to play crucial roles in the development and progression of endometriosis, and thus the disease may be considered an immune-related chronic inflammatory disease (2,3).…”

The density of nervous fiber and nucleus isoforms expression of estrogen and progesterone receptors in eutopic endometrium in patients with peritoneal endometriosis: pregnancy outcomes

“…Учи-тывая, что эндометриоз является заболеванием, свя-занным с увеличением инфламаторной активности в брюшной полости, на брюшине и в эутопическом эндометрии, эти изменения объективно снижают шанс наступления беременности [35] и, следователь-но, полученные результаты вполне объяснимы. Тем не менее у обследованных больных отсутствовали Основные иммуногистохимические характеристики фенотипических особенностей эутопического эндометрия у боль-ных с перитонеальной формой эндометриоза в зависимости от наступления беременности.…”