ORIGINAL ARTICLE: Developmental Delay and Other Anomalies in the Offspring from Hens Immunized Against Soluble and Foreign Chick Embryo Antigens

Rodriguez-Burgos, A; Juárez, Luis Manuel Terán

doi:10.1111/j.1600-0897.2008.00606.x

Cited by 4 publications

(3 citation statements)

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“…This is the first published report of histopathological lesions induced by fEIA isoantibodies . The macroscopic study of all descendants from hens immunized with chicken embryo extract (a total of 81 chick embryos) and control hens [66 embryos] led Rodríguez‐Burgos and Juárez to state the following: ‘By applying the statistical analysis to the different subgroups from experimental and [control] embryos, classified according to the displayed anomalies, we obtained the following results: monsters and malformations 8 / 81 and [3 / 66] (there were no significant differences); intraovo growth retardation (IOGR) and (delayed development: DD) 14/81 and [4 / 66] ( P = 0.063); DD and (IOGR) 34 / 81 and [1/66] ( P = 0.017); died by functional anomalies and digested embryos 10 / 81 and [4 / 66] ( P = 0.037); survived more than a week with anomalies 3 / 10 and [0 / 8] ( P = 0.004). Finally, birds without anomalies (normals) were 21 / 81 and [46/66] ( P ≤ 0.001)’.…”

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History of Foreign Embryonic IsoAntigens

Rodriguez-Burgos

2013

American J Rep Immunol

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After defining the term 'foreign embryonic isoantigens', the author describes the experimental sequence which has allowed this new fetoprotein class to be identified. Experiments have followed three different directions, namely (i) passive immunization, by which conceptus antibodies raised in another animal species are transferred to the female animal, the effects on the offspring becoming apparent after pregnancy; (ii) laboratory techniques, where the presence of conceptus antibodies in serum from aborting women has been demonstrated by use of analytical techniques or by testing the serum on cultured embryos; and (iii) active isoimmunization, by which the female animal is immunized against a conceptus extract from the same species, and the effects on the offspring are observed after pregnancy. The immunologic basis for autoantigenicity in these fetoproteins, and its significance to materno-fetal medicine, are explained. Finally, some fetoproteins not yet unambiguously classed as foreign embryonic isoantigens are presented.

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Section: Introductionmentioning

confidence: 99%

History of Foreign Embryonic IsoAntigens

Rodriguez-Burgos

2013

American J Rep Immunol

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“…12 Previous research has suggested that immune mechanisms may play a critical role in the development of human congenital defects. 13 IL-27 is a novel heterodimeric cytokine that consists of IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3). [14][15][16] IL-27, with its gene located on chromosome 16 (16p11), is a new IL-12 family member.…”

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“…In addition, there are a large number of cytokines involved in embryogenesis 12 . Previous research has suggested that immune mechanisms may play a critical role in the development of human congenital defects 13 …”

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confidence: 99%