ORIGINAL ARTICLE: Anti‐Elastin Antibodies and Elastin Turnover in Normal Pregnancy and Recurrent Pregnancy Loss

Konova, E; Aleksovska, T.; Atanasova, Milena; Georgieva, Miglena; Todorova, K; Lukanov, Tzvetan; Shoenfeld, Yehuda

doi:10.1111/j.1600-0897.2008.00678.x

Cited by 10 publications

(4 citation statements)

References 34 publications

(80 reference statements)

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“…Particularly relevant is the frequent association of antithyroid antibodies, which have been detected in 28 women, corresponding to 53.84% of RPL women ANA+. 37 Therefore, on the basis of these findings, it could be hypothesized that if the detection of ANA in a significant proportion of women with RPL can be interpreted as the expression of some derangement in the immune response or status in these subjects, then the detection of additional types of autoantibodies could represent the expression of a more marked disorder. However, emerging experimental evidence suggests that autoantibodies are implicated in pregnancy loss 10 through several potential pathogenetic mechanisms that involve a) reduction of embryo and yolk sac growth 34 as well as of trophoblast proliferation; 35 b) increase in the rate of trophoblast apoptosis; 35 adverse actions on molecules important for embryo and placental development such as laminin-1 36 and elastin.…”

Section: Discussionmentioning

confidence: 99%

“…However, emerging experimental evidence suggests that autoantibodies are implicated in pregnancy loss 10 through several potential pathogenetic mechanisms that involve a) reduction of embryo and yolk sac growth 34 as well as of trophoblast proliferation; 35 b) increase in the rate of trophoblast apoptosis; 35 adverse actions on molecules important for embryo and placental development such as laminin-1 36 and elastin. 37 Therefore, on the basis of these findings, it could be hypothesized that if the detection of ANA in a significant proportion of women with RPL can be interpreted as the expression of some derangement in the immune response or status in these subjects, then the detection of additional types of autoantibodies could represent the expression of a more marked disorder. In this context, and with specific application to antithyroid antibodies, it is interesting to consider that high prevalence of ANA positivity has been reported in patients with autoimmune thyroid disease.…”

Section: Discussionmentioning

confidence: 99%

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Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Ticconi

Rotondi

Veglia

et al. 2010

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Ticconi

Rotondi

Veglia

et al. 2010

American J Rep Immunol

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“…These interactions activate intracellular signalling pathways that lead to diverse cellular events, such as increased elastase production, release of free radicals, cell proliferation, and chemotactic activity of monocytes, fibroblasts and tumour cells (Fü löp et al, 1998;Labat-Robert, 2004). The disruption of elastin is not just an end product of elastin turnover but may also be an important contributor to the pathogenesis of tissue injury (Konova et al, 2009). In the present study, the levels of both the synthesis and degradation of elastin appeared to be significantly higher in pregnant women with toxoplasmosis than in healthy pregnant women or in healthy nonpregnant women.…”

Section: Mmp-12 and Elastin In Toxoplasmosismentioning

confidence: 99%

Elevated concentrations of matrix metalloproteinase-12 and elastin degradation products in the sera of pregnant women infected withToxoplasma gondii

2011

Annals of Tropical Medicine & Parasitology

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Although the expression of matrix metalloproteinase-12 (MMP-12) appears to be increased in most inflammatory diseases, the role of this enzyme in the pathogenesis of toxoplasmosis in pregnant women, if any, is unknown. In a recent study in Taiwan, the serum concentrations of MMP-12 and its substrate elastin were evaluated in pregnant women with Toxoplasma gondii infection. Compared with the healthy pregnant and non-pregnant women used as controls, the pregnant women with toxoplasmosis had significantly higher serum concentrations of MMP-12 and significantly higher levels of elastin synthesis and degradation. Interaction between MMP-12 and elastin in the serum samples was confirmed by co-immunoprecipitation. It seems possible that MMP-12 may contribute to elastin degradation occurring during the pathogenesis of toxoplasmosis in pregnant women.

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“…For example, significantly higher levels of anti-saccharomycetes cerevisiae antibodies (ASCA) [34] and anti-Elastin antibodies [35] have been reported in women with a history of recurrent pregnancy loss.…”

Section: Anti-phospholipid Antibody Syndrome and Rplmentioning

confidence: 99%

Effective Treatment for Recurrent Pregnancy Loss

Makino

2010

RIB

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Abstract:Understanding the etiology of recurrent pregnancy loss (RPL) has been increasing in importance in reproductive medicine, especially in societies with low birth rates. Since the cause of human miscarriage is often complicated and multifactorial, effective treatment for the successful maintenance of pregnancy requires the comprehensive clinical management of recurrent wastages. Immunology for the maintenance of pregnancy is a very attractive field; however, the role of immunology during human gestation cannot be confirmed in couples with a history of recurrent pregnancy loss unless other clinical causes of miscarriage are especially ruled out. Balanced chromosomal rearrangements have been found at an increased frequency in couples with recurrent pregnancy loss compared with the general population. The major anomalies are Robertosonian or reciprocal translocations, while most minor variants include pericentric inversion of chromosome 9. Both major and minor anomalies result in a spontaneous abortion rate of approximately 80-90%. Though the incidences of these chromosomal abnormalities vary in reported studies, a survey indicated an incidence of 9.8% (3.9% in male partners and 5.9% in female partners) among 1,639 couples with a history of recurrent pregnancy loss. Congenital uterine anomaly resulting in a suboptimal uterine environment may influence ovum implantation and early fetal development and may be a candidate in the etiology of reproductive wastage. A review on the relation between congenital uterine anomalies and the spontaneous abortion rate concluded that a precise diagnosis of uterine cavity deformity, especially arcuate uterus, is a key issue for determining the clinical prognosis during human gestation. After establishing diagnostic criteria for uterine cavity anomaly, 278 congenital uterine anomalies were detected in a series of 2,061 hysterosalpingographies (13.5%) performed in women with a history of recurrent pregnancy loss. Among these abnormalities, the incidences of spontaneous abortion were equally high among patients with arcuate uterus and those with partial septate uterus. A few studies on abortion mechanism in patients with congenital uterine anomalies have been reported. Histological findings using CD34-positive staining indicate the lack of a blood capillary system in both the uterine septum and the fundus muscle layer. The results of metroplastic surgery on congenital uterine anomaly are also controversial. Based on our fundamental findings of the maldistribution of uterine capillaries, we performed ideal metroplastic surgery in 173 women and significantly

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ORIGINAL ARTICLE: Anti‐Elastin Antibodies and Elastin Turnover in Normal Pregnancy and Recurrent Pregnancy Loss

Abstract: Elastin degradation is decreased during normal pregnancy. Increased anti-elastin IgG antibodies may contribute to the pathogenesis of pregnancy losses.

Cited by 10 publications

References 34 publications

Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Antinuclear Autoantibodies in Women with Recurrent Pregnancy Loss

Elevated concentrations of matrix metalloproteinase-12 and elastin degradation products in the sera of pregnant women infected withToxoplasma gondii

Effective Treatment for Recurrent Pregnancy Loss

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