ORIGINAL ARTICLE: Abnormal Pattern of Lymphocyte Subpopulations in the Endometrium of Infertile Women with Chronic Endometritis

Matteo, Maria; Cicinelli, Ettore; Greco, Pantaleo; Massenzio, Francesca; Baldini, Domenico; Falagario, Teresa; Rosenberg, Piergiorgio; Castellana, Laura; Specchia, Giorgina; Liso, Arcangelo

doi:10.1111/j.1600-0897.2009.00698.x

Cited by 99 publications

(84 citation statements)

References 41 publications

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“…It is therefore possible to speculate that a chronic inflammatory process in the endometrium could influence JZ functionality. In women with CE, an abnormal pattern of lymphocyte subsets and, consequently, an aberrant endometrial microenvironment have been demonstrated (18,19). It is possible to speculate that the altered leukocyte population and the altered pattern of paracrine factors could influence the nearby endometrium of the JZ, inducing an altered contractility.…”

Section: Discussionmentioning

confidence: 97%

Altered uterine contractility in women with chronic endometritis

Pinto

Matteo

Tinelli

et al. 2015

Fertility and Sterility

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Section: Discussionmentioning

confidence: 97%

Altered uterine contractility in women with chronic endometritis

Pinto

Matteo

Tinelli

et al. 2015

Fertility and Sterility

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“…These findings were in agreement with one immunohistochemical study, 7 but not with a flow cytometric study that showed the decrease in NK cell proportion and increase in T-cell proportion in chronic endometritis. 28 The discrepancy may be due to a difference in methodology. In addition, the number of neutrophils, a hallmark of acute endometritis was similar in the chronic endometritis and nonpathological endometrium.…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis

2010

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Chronic endometritis is often identified in the patients with unexplained infertility, and is histopathologically characterized by infiltration of plasmacytes within the endometrial stroma. In parallel with stromal plasmacyte infiltration, the endometrial functional layer in chronic endometritis is invaded by B cells, which are a rare leukocyte subset residing within the basal layer in the nonpathological endometrium. In this study, we investigated the molecular expression underlying this unusual increase of B cells in chronic endometritis. Twenty-two out of 76 infertile patients were diagnosed with chronic endometritis from the stromal plasmacyte infiltration, and the endometrium contained numerous stromal B-cell aggregates and glandular single B cells. However, the other major leukocyte subsets, including T cells, natural killer cells, macrophages, and neutrophils were comparable in densities in chronic endometritis and nonpathological endometrium. The microvascular endothelium showed immunoreactivity to adhesion molecule selectin E and chemokine CXCL13 along with immunoreactivity to CXCL1 in the glandular epithelium in chronic endometritis, but not in the nonpathological endometrium. Lipopolysaccharide significantly induced surface selectin E expression and CXCL13 secretion in uterine microvascular endothelial cells, and CXCL1 secretion in endometrial epithelial cells in vitro. These findings indicated that the aberrant local microenvironment triggered possibly by bacterial infection has a role in selective extravasation of circulating B cells in chronic endometritis.

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“…A hysteroscopy-guided endometrial biopsy is assumed to be the method of choice to ensure the integrity of the uterine cavity before IVF (6). Although infiltration of the endometrium by lymphocytes and eosinophils is associated with chronic endometritis, the diagnosis is ultimately based on the presence of plasma cells in the endometrial stroma (7)(8)(9)(10). The search for plasma cells may be hampered by many factors such as inadequate staining, preservation of the endometrial tissue, or mimicking of plasma cells by plasmacytoid stroma cells (7,8,11).…”

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confidence: 99%