Origin of IgA-secreting plasma cells in the mammary gland.

Roux, M; McWilliams, Michael; Phillips‐Quagliata, Julia M.; Weisz-Carrington, Paul; Lamm, Michael E.

doi:10.1084/jem.146.5.1311

Cited by 336 publications

(154 citation statements)

References 33 publications

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“…The affinity of lymphoblasts to secretory tissue such as mammary and salivary glands has been reported in earlier studies (39,40). The detection of radioactivity in lactating mammary glands after transfer of radiolabeled rat T cells into naive animals led to the conclusion that T cells play a role in maternal-to-neonatal transfer of immunity (41).…”

Section: Discussionsupporting

confidence: 63%

Extrafollicular Plasmablast B Cells Play a Key Role in Carrying Retroviral Infection to Peripheral Organs

Finke

Baribaud

Diggelmann

et al. 2001

The Journal of Immunology

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B cells can either differentiate in germinal centers or in extrafollicular compartments of secondary lymphoid organs. Here we show the migration properties of B cells after differentiation in murine peripheral lymph node infected with mouse mammary tumor virus. Naive B cells become activated, infected, and carry integrated retroviral DNA sequences. After production of a retroviral superantigen, the infected B cells receive cognate T cell help and differentiate along the two main differentiation pathways analogous to classical Ag responses. The extrafollicular differentiation peaks on day 6 of mouse mammary tumor virus infection, and the follicular one becomes detectable after day 10. B cells participating in this immune response carry a retroviral DNA marker that can be detected by using semiquantitative PCR. We determined the migration patterns of B cells having taken part in the T cell-B cell interaction from the draining lymph node to different tissues. Waves of immigration and retention of infected cells in secondary lymphoid organs, mammary gland, salivary gland, skin, lung, and liver were observed correlating with the two peaks of B cell differentiation in the draining lymph node. Other organs revealed immigration of infected cells at later time points. The migration properties were correlated with a strong up-regulation of α4β1 integrin expression. These results show the migration properties of B cells during an immune response and demonstrate that a large proportion of extrafolliculary differentiating plasmablasts can escape local cell death and carry the retroviral infection to peripheral organs.

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Section: Discussionsupporting

confidence: 63%

Extrafollicular Plasmablast B Cells Play a Key Role in Carrying Retroviral Infection to Peripheral Organs

Finke

Baribaud

Diggelmann

et al. 2001

The Journal of Immunology

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“…After the beginning of lactation the bulk of women Abz activities belong to milk IgGs and especially to sIgAs, while the specific activities of the serum Abzs are significantly lower [2][3][4][5]18,24]. sIgA is selectively produced by plasma cells residing in the interstitial tissue underlying the epithelial surfaces of the lactating breast [34]. These lymphoid cells migrate to the breast from the maternal intestinal lymphoid tissues (Peyer's patches) and from lymphoid centers in the bronchial tree [34,35].…”

Section: Resultsmentioning

confidence: 99%

Antibodies with amylase activity from the sera of autoimmune‐prone MRL/MpJ‐lpr mice

Andryushkova

Кузнецова

Orlovskaya³

et al. 2006

FEBS Letters

259

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Animals spontaneously developing lupus-like autoimmune pathology (SLE) are very promising models to study the mechanisms of natural abzymes (Abzs) generation and their role in etiology and pathogenesis of autoimmune diseases, but Abzs from the sera of animals remain virtually unstudied. In this work, electrophoretically homogeneous IgGs were isolated from the sera of MRL/MpJ-lpr mice. It was shown for the first time that amylase activity is an intrinsic property of antibodies (Abs) and their isolated heavy and light chains. Various markers of SLE pathology (proteinuria, enhanced concentration of anti-DNA Abs) increased with spontaneous development of SLE and especially after animal immunization, correlating with the increase in Abz relative amylase activity. The highest amylase activity was found in the sera Abs of healthy mice after delivery and at the beginning of lactation; this was not correlated with markers of mouse SLE but supports the idea that pregnancy could ''activate'' or ''trigger'' autoimmune-like manifestations and Abzs production in healthy mammals. The possible differences in mechanisms of Abzs production in lactating mice and animals developing SLE are discussed.

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“…C'est le cas des cellules à IgA et IgM. De manière spécifique, dans les conditions naturelles, la stimulation dans le GALT des plasmocytes à IgA par des antigènes induit leur migration vers la glande mammaire où ils sécrètent des IgA du colostrum et du lait (Roux et al, 1977). Chez la truie, ces plasmocytes à IgA activés atteignent la glande mammaire grâce aux adressines et chimiokines et c'est l'absence de ces adressines dans la glande mammaire des ruminants qui explique l'absence des plasmocytes à IgA (Levast, 2010 ;Salmon, 2011).…”

Section: Composition Du Colostrum Et Synthese De Ses Composantsunclassified

Physiologie de l’immunité colostrale chez les porcins et facteurs de variation du rendement et de la qualité immunitaire du colostrum de la truie

Agbokounou¹,

Ahounou²,

Karim³

et al. 2017

Int. J. Bio. Chem. Sci

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RESUMEChez les porcins comme chez d'autres mammifères, le colostrum apporte des substances nutritives et des facteurs immunitaires pour compenser l'immunité non transmise avant la naissance et le déficit énergétique avec lequel naissent les porcelets. Le colostrum est alors un aliment déterminant dans la survie du porcelet pendant les premières heures de sa vie et par conséquent un facteur important de la productivité de la truie. Le mécanisme de sa synthèse et du transfert de l'immunité au nouveau-né est complexe et mérite d'être bien cerné en vue d'assurer la survie du porcelet. La présente revue a non seulement décrit les mécanismes de synthèse des composants immunitaires et de leur transfert au nouveau-né, mais a fait aussi l'état des lieux de récents travaux sur les facteurs influençant la quantité et la qualité immunitaire du colostrum chez la truie. L'accent a été alors mis sur la composition du colostrum, la synthèse des composés nutritifs et immunitaires (transfert des immunoglobulines du sang dans la glande mammaire et leur synthèse locale), le transfert des immunoglobulines et des cellules immunitaires au porcelet et les facteurs endogènes et exogènes influençant la quantité et la qualité immunitaire du colostrum de la truie. © 2017 International Formulae Group. All rights reserved.Mots clés : Colostrum, immunité, espèce porcine, immunoglobuline.A. M. AGBOKOUNOU et al. / Int. J. Biol. Chem. Sci. 11(1): 420-443, 2017 421 Physiology of colostral immunity and factors influencing yield and immune quality of sow colostrum ABSTRACTIn pigs as in other mammals, colostrum provides nutrients and immune factors to compensate the nontransmitted immunity before birth and the energy deficit with which piglets are born. Colostrum intake is then crucial for piglet survival during the first hours of life and therefore for sows productivity. The mechanism of its synthesis and immunity transfer to the newborn is complex and deserves to be well defined in order to ensure piglet survival. This review describes the synthesis mechanisms of immune components and their transfer to the newborn. It also provides an update of recent research on the factors influencing the quantity and immune quality of colostrum in sows. Emphasis was then placed on the colostrum composition, synthesis of nutrients and immune compounds (transfer of blood immunoglobulins in the mammary gland and their local synthesis), the transfer of immunoglobulins and immune cells in the piglet and endogenous and exogenous factors affecting the quantity and immune quality of colostrum from the sow.

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Origin of IgA-secreting plasma cells in the mammary gland.

Cited by 336 publications

References 33 publications

Extrafollicular Plasmablast B Cells Play a Key Role in Carrying Retroviral Infection to Peripheral Organs

Extrafollicular Plasmablast B Cells Play a Key Role in Carrying Retroviral Infection to Peripheral Organs

Antibodies with amylase activity from the sera of autoimmune‐prone MRL/MpJ‐lpr mice

Physiologie de l’immunité colostrale chez les porcins et facteurs de variation du rendement et de la qualité immunitaire du colostrum de la truie

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