2007
DOI: 10.1038/sj.bjp.0707373
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Origin and evolution of high throughput screening

Abstract: This article reviews the origin and evolution of high throughput screening (HTS) through the experience of an individual pharmaceutical company, revealing some of the mysteries of the early stages of drug discovery to the wider pharmacology audience. HTS in this company (Pfizer, Groton, USA) had its origin in natural products screening in 1986, by substituting fermentation broths with dimethyl sulphoxide solutions of synthetic compounds, using 96-well plates and reduced assay volumes of 50-100ml. A nominal 30m… Show more

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Cited by 296 publications
(209 citation statements)
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“…Biotechnology has established itself as an "industry" dedicated to drug discovery and its success is evident when one observes its use for these kind of activity (Drews, 2000, Hopkins et al 2007Pereira and Williams, 2007). The adaptation of biotechnology to this type of activity was successful, especially, regarding the technology and knowledge appropriation conducted by large pharmaceutical companies.…”
Section: Drug Discovery Afterbiotechnologymentioning
confidence: 99%
See 1 more Smart Citation
“…Biotechnology has established itself as an "industry" dedicated to drug discovery and its success is evident when one observes its use for these kind of activity (Drews, 2000, Hopkins et al 2007Pereira and Williams, 2007). The adaptation of biotechnology to this type of activity was successful, especially, regarding the technology and knowledge appropriation conducted by large pharmaceutical companies.…”
Section: Drug Discovery Afterbiotechnologymentioning
confidence: 99%
“…The High Throughput Screening (HTS) is one of the most prominent biotechnology and it has increased, significantly, the capacity of enterprises to screen new compounds through patronization and automatization (Nigtingale, 2000;Pereira and Williams, 2007).…”
Section: Drug Discovery Afterbiotechnologymentioning
confidence: 99%
“…High-throughput screening (HTS) has developed over the last 2 decades as the principal method of lead identification in drug discovery (20). With advances in molecular biology and genomics, target-based screens, which detect small modulators of proteins, have overtaken traditional phenotypic screens in HTS applications (21).…”
Section: T He Cyclic-amp Response Element Binding (Creb) Proteinmentioning
confidence: 99%
“…It has been the mainstay for lead identification in the pharmaceutical industry for the past two decades (Pereira & Williams, 2007;Macarron et al, 2011). Typically, 10 000 compounds are screened per day to identify hits that show a therapeutic response, with hit compounds being progressed into hit-to-lead development.…”
Section: Introductionmentioning
confidence: 99%