Origanum spp.: an update of their chemical and biological profiles

Marrelli, Mariangela; Statti, Giancarlo; Conforti, Filomena

doi:10.1007/s11101-018-9566-0

Cited by 41 publications

(32 citation statements)

References 50 publications

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“…hirtum (HCOE) was investigated on highly metastatic and drug-resistant murine (B16-F10) and human (A375) melanoma cells. Indeed, although a potential antineoplastic effect has been associated to oregano extracts [ 30 , 31 , 32 , 33 , 34 , 35 ], the capacity of this herb to contrast the growth of the above-mentioned melanoma lines has never been elucidated in detail. Moreover, as one of the main goals of the cancer research is the discovery of new drugs with limited or without adverse side effects for healthy tissues, oregano extract was also tested on C2C12 myoblasts, which is a non-tumor cell model.…”

Section: Discussionmentioning

confidence: 99%

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Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage

Nanni

Marco

Sacchetti

et al. 2020

Foods

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Plant secondary metabolites possess chemopreventive and antineoplastic properties, but the lack of information about their exact mechanism of action in mammalian cells hinders the translation of these compounds in suitable therapies. In light of this, firstly, Origanum vulgare L. hydroalcoholic extract was chemically characterized by spectrophotometric and chromatographic analyses; then, the molecular bases underlying its antitumor activity on B16-F10 and A375 melanoma cells were investigated. Oregano extract induced oxidative stress and inhibited melanogenesis and tumor cell proliferation, triggering programmed cell death pathways (both apoptosis and necroptosis) through mitochondria and DNA damage. By contrast, oregano extract was safe on healthy tissues, revealing no cytotoxicity and mutagenicity on C2C12 myoblasts, considered as non-tumor proliferating cell model system, and on Salmonella strains, by the Ames test. All these data provide scientific evidence about the potential application of this food plant as an anticancer agent in in vivo studies and clinical trials.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, some literature works have also associated a strong anticancer activity to such type of plant extract. For these reasons, O. vulgare is capturing greatly the attention of the food, cosmetic, and pharmaceutical industries [ 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage

Nanni

Marco

Sacchetti

et al. 2020

Foods

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“…Nitrogen is involved in the formation of many plant organic compounds and has positive effects on plant growth due to its positive effects on photosynthetic activity and metabolic processes of organic compounds in the plant and enhance vegetative growth (Singh et al, 2004). So, good nutrition of plants plays an important role in their resistance to various types of living and non-living stresses (Marrelli et al, 2018). A plant that is well-nourished and has sufficient nutrients will have better resistance to dehydration and will be affected by the quantity and quality of the product.…”

Section: Introductionmentioning

confidence: 99%

Effect of Nitrogen Fertilizers on Yield and Antioxidant Enzymes of Basil (Ocimum basilicum L.) under Water Stress Conditions

2019

JSTR

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Water scarcity in Iran has always been a limiting factor for crop and horticultural production. Under these conditions, the nutrient uptake and metabolism processes of plants are different and can reduce growth. To study water stress (at three levels) and six fertilizer regimes (Nitrogen fertilizer requirement by a combination of vermicompost and urea fertilizer) on the quantitative yield of experimental basil (Ocimum basilicum L.). Results showed that water deficit treatment reduced leaf chlorophyll content, leaf soluble proteins, shoot dry weight and essential oil yield. The highest concentration of total chlorophyll and leaf soluble protein was obtained in normal irrigation and fertilizer regime of 1 ton vermicompost. And water deficit stress reduced these two traits. The lowest activity of antioxidant enzymes was obtained under non-stress conditions. Increasing of water deficit stress increased the activity of these antioxidants among fertilizer treatments. The highest activity of this antioxidant was obtained in non-fertilizer treatment and by adding vermicompost fertilizer to fertilizer treatment of this antioxidant. Forks also declined. The shoot dry weight and essential oil yield decreased under water deficit stress. Increasing vermicompost share in fertilizer treatments led to increased yield. The percentage of essential oil increased with moderate irrigation and decreased again with severe irrigation. In general, the results showed that vermicompost had a positive effect on both vegetative and physiological traits of the plant.

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“…Among the different Origanum species, several are commonly used for culinary purposes (especially as spices), such as the Greek oregano ( Origanum vulgare L. ssp. hirtum (Link) Ietswaart), Marjoram ( Origanum marjorana L.), Turkish oregano ( Origanum onites L.), round-leaved oregano ( Origanum rotundifolium L.), or Syrian oregano ( Origanum syriacum L.) [ 72 , 73 , 74 ]. The Origanum spp.…”

Section: Different Medicinal and Aromatic Plants—different Applicamentioning

confidence: 99%

“…The Origanum spp. plants, especially leaves, are rich in terpenes (monocyclic terpenes—from which the most concentrated are carvacrol and thymol; bicyclic monoterpenes such as thujene, sabinene, camphene, α and β pinene; acyclic monoterpenes such as linalool; sesquiterpenes such as β-bisabolene; triterpenoids such as ursolic and oleanolic acids) [ 75 ] and phenolic compounds (hydroquinone and derived compounds; phenolic acids: p-hydroxybenzoic, vanillic, syringic; flavonoids) [ 72 ], but the composition depends on different factors (species, cultivation area, environment conditions, harvesting time, phenopase, etc.).…”

Section: Different Medicinal and Aromatic Plants—different Applicamentioning

confidence: 99%

Selected Aspects Related to Medicinal and Aromatic Plants as Alternative Sources of Bioactive Compounds

Fierăscu

Baroi

et al. 2021

IJMS

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Natural compounds obtained from different medicinal and aromatic plants have gained respect as alternative treatments to synthetic drugs, as well as raw materials for different applications (cosmetic, food and feed industries, environment protection, and many others). Based on a literature survey on dedicated databases, the aim of the present work is to be a critical discussion of aspects regarding classical extraction versus modern extraction techniques; possibilities to scale up (advantages and disadvantages of different extraction methods usually applied and the influence of extraction parameters); and different medicinal and aromatic plants’ different applications (medical and industrial applications, as well as the potential use in nanotechnology). As nowadays, research studies are directed toward the development of modern, innovative applications of the medicinal and aromatic plants, aspects regarding future perspectives are also discussed.

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Origanum spp.: an update of their chemical and biological profiles

Cited by 41 publications

References 50 publications

Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage

Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage

Effect of Nitrogen Fertilizers on Yield and Antioxidant Enzymes of Basil (Ocimum basilicum L.) under Water Stress Conditions

Selected Aspects Related to Medicinal and Aromatic Plants as Alternative Sources of Bioactive Compounds

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