Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCα/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

“…Epidermal growth factor/ERK/pS-STAT3, but not IFN-g/pY-STAT3, enhanced STAT3-regulated thyroglobulin-releasing hormone expression, while only transiently expressing SOCS3, which, in contrast, had a prolonged expression through IFN-g/pY-STAT3, which failed to upregulate thyroglobulin-releasing hormone. pS-STAT3 also interacts with other transcription factors, e.g., nuclear factor kB (NF-kB), to transcribe differing but overlapping sets of genes (Kim et al, 2018;Coorens et al, 2019;Li et al, 2019), with varying transcriptional responses in endothelial cells thought to correlate with increasing stress and increased levels of pS727 phosphorylation (Kurdi and Booz, 2010). For example, in conditions of minimal stress, there are minimal levels of pS727, and pY705mediated transcription dominates.…”

Quinoa Secondary Metabolites and Their Biological Activities or Functions

“…About 29 phenolic acid analogues have been identified in quinoa. According to their structural features, they can be classified as benzoic acid analogues (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and cinnamic acid analogues (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Benzoic acid (1) was derived from cinnamic acid (19) in planta in the biosynthetic pathway of phenolic acids [24].…”

“…Benzoic acid (1) Leaves and flour - [27,33] 4-Hydroxybenzoic acid = p-Hydroxybenzoic acid (2) Seeds - [25] Leaves and seeds - [27,34] (5) Seeds - [35] Canthoside A (6) Flour - [33] Ethyl-m-digallate (7) Flour - [33] Antifeedant activity [32] Gallic acid (8) Leaves, sprouts and seeds - [27,34] Antioxidant activity [31] Antibacterial activity [36] 1-O-Galloyl-β-d-glucoside (9) Seeds and flour - [33] Protocatechuic acid (10) Sprouts and seeds - [25,37] Antioxidant activity [31] Anticancer activity [38] Antibacterial activity [39] Antiulcer activity [40] Antiageing activity [41] Anti-inflammatory, antiibrotic, antiatherosclerotic, hyperlipidemic, analgesic, hepatoprotective and nephroprotective activities [42] Antiviral activity [43]…”

“…The year 2013 was named "The Internaitonal Year of Quinoa" by the UN. Quinoa has been introduced and cultivated all over the world in the past ten years [3][4][5][6][7][8].…”

The Role of MMP-2 and MMP-9 in Breast Cancer

“…58 Bir glikozil diyet flavonoidi olan Orientin (luteolin 8-C-β-D-glukopiranosid), MCF-7 hücrelerine uygulandığında protein kinaz C α'nın zar translokasyonunu ve ERK'nin fosforilasyonunu düşürmektedir. Böylelikle MMP-9 ekspresyonunu baskılayarak kan- 59 Antikanser bir bileşik olan Luteolin'in, sitotoksik olmayan konsantrasyonlarda (0, 5 ve 10 µM) MMP-9 ekspresyonunu azaltarak, tümör promotörü 12-0-tetradekanoilphorbol-13-asetat ile muamele edilmiş MDA-MB-231 meme kanseri hücrelerinde, migrasyon ve invazyonu inhibe ettiği bildirilmektedir. 32 Sonuç olarak bu derleme, MMP-2 ve MMP-9'un meme kanseri hücrelerinin migrasyon, invazyon, proliferasyon ve anjiyogenezine dâhil olduğunu göstermektedir.…”