Organotin flufenamates: Synthesis, characterization and antiproliferative activity of organotin flufenamates

Antiproliferative and anti-tumor activity of organotin compounds

“…A possible reason is that (ArCH 2 ) 2 Sn(Cl)S 2 CNR 2 can hydrolyze more easily and release (ArCH 2 ) 2 Sn 2+ in comparison with (ArCH 2 ) 2 Sn(S 2 CNR 2 ) 2 . [55] were evaluated for antiproliferative activity in vitro. Among the compounds tested 174 and 175 exhibited high cytotoxic activity against the cancer cell line A549 (Table 5).…”

The triphenyltin(VI) complexes of NSAIDs and derivatives. Synthesis, crystal structure and antiproliferative activity. Potent anticancer agents

“…The anti-inflammatory activity of Hdcpa (3) was measured by the anti-UV-erythema test and the minimum effective dose (MED) was found to be 3.1 mg/kg, while for flufenamic and tolfenamic the MED value was found to be 3.3 and 5.3 mg/kg, respectively [6]. Crystal structures of dimeric tetraorganodistannoxanes of flufenamic, mefenamic, meclofenac, Hdcpa and Hmpa have been reported [7][8][9][10]. The crystal structures of triphenyltin(IV) esters of mefenamic acid, meclofenamic (9) and Hdmpa (5) have been also reported and were tested for antimycobacterial activity against Mycobacterium tuberculosis H37Rv.…”

“…Crystal structures of dimeric tetraorganodistannoxanes of flufenamic, mefenamic, meclofenac, Hdcpa and Hmpa have been reported [7][8][9][10]. The crystal structures of triphenyltin(IV) esters of mefenamic acid, meclofenamic (9) and Hdmpa (5) have been also reported and were tested for antimycobacterial activity against Mycobacterium tuberculosis H37Rv. These triphenyltin esters were found to be very good anti-tuberculosis agents [11][12][13][14].…”

The Effectiveness of Organotin (IV) Benzylisopropyldithiocarbamate Compounds as Insecticide Against <i>Aedes Aegypti</i> Linn (Diptera: Culicidae) in Laboratory

“…Among the biological activities of organotin (IV) compound have these compounds identified as a potential antiviral agent (Sreeja and Kurup, 2005), antineoplastic agents, antituberculosis (Gielen, 2002;Dokorou et al, 2004;Kovala-Demertzi et al, 2005;Kovala-Demertzi, 2006), antibacterial agent (Jamil et al, 2009), anticancer agent (Awang et al, 2010) and so on.…”