The triphenyltin(VI) complexes of NSAIDs and derivatives. Synthesis, crystal structure and antiproliferative activity. Potent anticancer agents

Synthesis, crystal structures and spectroscopy of meclofenamic acid and its metal complexes with manganese(II), copper(II), zinc(II) and cadmium(II). Antiproliferative and superoxide dismutase activity

“…Infrared and far-infrared spectra were recorded on a Perkin Elmer Spectrum GX Fourier transform spectrophotometer using KBr pellets (4000-400 cm − 1 ) and nujol mulls dispersed between polyethylene disks (400-40 cm − 1 ). ΝΜR spectra were recorded on a Bruker AV-400 spectrometer operating at 400 and 100 MHz for 1 H and 13 C acquisition, respectively, or on a Bruker AV-250 spectrometer operating at 250.13 and 62.90 MHz for 1 H and 13 C acquisition respectively. The spectra were acquired at room temperature (298 K).…”

“…The information collected from the preparative, structural and reactivity studies have high significance for several fields which span from the bio-sciences to the material sciences. The combination of two or more different species into the same compound may bring to a multi-therapeutic agent which can be expanded by the synergic action of the metal residue once the coordination compound dissociates inside the target tissue [12,13,15,17].…”

“…Some complexes have increased pharmaceutical or biological activity with respect to the drug or are interesting from a purely chemical point of view [10][11][12][13][14][15][16][17]. A review of the synthesis and crystal structures of a number of anti-inflammatory compounds as ligands in organotin complexes and a review of copper complexes with NSAIDs have been reported [6,10,14,16].…”

Understanding the structure of salicyl hydrazone metallocomplexes: crystal structure, AIM and Hirshfeld surface analysis of trichloro-(N-salicylidenebenzoylhydrazinato-N,O,O′)-tin(IV)

“…Tin possess a considerable structural diversity that attracts an ongoing interest in its coordination chemistry [1][2][3][4][5]. A number of tin compounds promote antimicrobial [6,7] and anticancer [8][9][10] activity. Besides, some of them are used as reagents and catalysts in organic reactions [11][12][13][14][15].…”

Self-assembly and antitumor activity of an organotin coordination polymer containing a helical structure based on copper cyanide and phenanthroline ligand

“…metallocenes [53,54], metalarene complexes [55], metal carbonyl, and carbene complexes [56]. Discovery of the antiproliferative and antitumor activity of cisplatin and its derivatives initiated the investigation for the possible therapeutic applications of other metal-based drugs, often organometallic compounds [57][58][59][60][61][62][63], and more particularly organotin(IV) compounds [64][65][66][67][68][69]. Many different metals have minimized side effects associated with the use of platinum compounds as anticancer drugs [60][61][62][63].…”