Organotin‐Drug Interactions. Organotin Adducts of Lornoxicam, Synthesis and Characterisation of the First Complexes of Lornoxicam

Abstract

The synthesis and spectral characterisation of novel organotin complexes [SnMe2(lorn)] (1) and [SnBu2(lorn)] (2) of the potent and widely used anti‐inflammatory drug lornoxicam, H2lorn, are reported. Crystal structure determinations of complexes1 and 2 showed that the ligand is doubly deprotonated at the oxygen and amide nitrogen atoms and is coordinated to the SnR2 fragment via four‐ and six‐membered chelate rings. The monomers of 1 are linked through intermolecular hydrogen bonds of C−H‐‐O type and through C−H−π intermolecular interactions. There are two similar molecules in the asymmetric unit of 2. The dimers of 2 are arranged in polymers with a stacking of alternate parallel chains and are linked through intermolecular hydrogen bonds of C−H‐‐O type, and through C−H−π intermolecular interactions. An extended network of Sn−O−Sn, C−H‐‐O and C−H‐‐π contacts lead to aggregation and a supramolecular assembly. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

Design of Meloxicam and Lornoxicam Transdermal Patches: Preparation, Physical Characterization, ex Vivo and in Vivo Studies

“…MX and LX were reported to have 0.1 and 1.8 log P values (the logarithm of the n-octanol/pH 7.4 buffer partition coefficient, P), respectively. 20,21) Therefore, results obtained from MX and LX met expectations on good transdermal penetration (Fig. 8).…”

“…This attitude can be attributed to the difference in n-octanol/pH 7.4 buffer partition coefficients of MX and LX as reported as log P 0.1 and 1.8, respectively. 20,21) Cumulative percentage of drug release versus square root of time curves shows linearity and it proves that all the formulations follows Higuchi model, suggesting that diffusion may be the mechanism of drug release. The correlation coefficients of Higuchi's plot of formulations are presented in Table 4.…”

Synthesis, characterization, and in vitro antimicrobial activities of organotin(IV) complexes of Schiff bases with ONO‐type donor atoms

“…The two phenyl rings in the ligand are also near to coplanar in opposite directions with show a negative peak shift in peak potentials, as well as an increase in current intensity, as shown in Table 4. The cyclic voltammetric data show that the reduction of the mentioned complexes is ligand centered [48,49]. The fact that in the voltammetric reduction of all the complexes, the reduction potentials of imine group are shifted to less-negative values compared to the ligand, can be taken as a further evidence that the ligation of the azomethine nitrogen does occur.…”

Synthesis, Spectroscopic Studies, and Crystal Structures of Phenylorganotin Derivatives with [Bis(2,6‐dimethylphenyl)amino]benzoic Acid: Novel Antituberculosis Agents

“…In the complexes 2 ± 4, HÀC (3) is deshielded due to s-charge donation from the COO À donor to the Sn center, which reduces the electron density at the ligand. The observed upfield shift for both HÀC(4) and C(4) para to the coordinating COO group could be due to a backflow of charge from the Sn-atom to the aromatic ring [7] [9] [23].…”