Design of Meloxicam and Lornoxicam Transdermal Patches: Preparation, Physical Characterization, ex Vivo and in Vivo Studies

Yener, Gülgün; Üner, Melike; Gönüllü, Ümit; Yıldırım, Sinem; Kiliç, Pınar; Aslan, Serap Saglik; Barla, Asli

doi:10.1248/cpb.58.1466

Cited by 30 publications

(27 citation statements)

References 17 publications

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“…The specimens of transdermal systems were placed on the working platform of the Texture Analyser with a double sided band. Using the test parameters above, the mean adhesive force (g) ± SD and the mean area under the curve (N.sn) ± SD were determined (21).…”

Section: Determination Of the Adhesive Properties Of Matrix Type Tranmentioning

confidence: 99%

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Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Kerımoğlu¹,

Şahbaz²,

Şehirli³

et al. 2015

mpj

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The objective of this study was to evaluate the mechanical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. The formulations were characterized in terms of their adhesiveness and bioadhesiveness by using texture analyser. These optimum formulations were chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using Franz Diffusion Cell. Results indicated that the mechanical properties of the formulations were suitable to be used as a transdermal patch.

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Section: Determination Of the Adhesive Properties Of Matrix Type Tranmentioning

confidence: 99%

“…There are numerous studies in the literature regarding the adhesiveness and bioadhesiveness of transdermal patches (21,22,(24)(25)(26). Sezer AD et al used chicken back skin as a model tissue to study the bioadhesion of fucoidanchitosan films.…”

Section: Adhesive and Bioadhesive Properties Of Matrix Type Transdermmentioning

confidence: 99%

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Kerımoğlu¹,

Şahbaz²,

Şehirli³

et al. 2015

mpj

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“…Topical application of NSAIDs can be an alternative route to overcome the GI side eff ects of NSAIDs, including LRX (3,4). Nanoparticles based on lipophilic materials like waxes or fats appear to be a ractive colloidal carrier systems for the delivery of drugs through distinct routes, including topical application (5,6).…”

mentioning

confidence: 99%

Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

et al. 2015

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O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin.

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“…Theoretical background concerning transbuccal penetration would indicate this pH value for buccal membrane. The p value falls within the proper range for potential drugs to penetrate the lipid phase of the buccal membrane (Dearden & Bresnen, 1988;Taylor, 1990;Earll, 1999;Yener et al, 2010).…”

Section: Lipophylicity Of Doxepinmentioning

confidence: 79%

Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

et al. 2014

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Tricyclic antidepressants, as doxepin hydrochloride (DH), may have analgesic local effect due to its biochemical mechanism of action. Delivery of DH directly to the oral cavity could be an interesting alternative for toothache due to its analgesic local effect. One problem associated with the mucosal administration routes is the short residence time of the dosage form on the mucosal membranes. In this sense, we have developed new doxepin mucoadhesive films able of reducing pain and increasing the effectiveness of treatment. For this purpose, we tested three different polymers: chitosan, sodium hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (SCMC) in film elaboration. The results obtained show that all films are hydrophilic matrices that absorb water when placed in an aqueous media. All the films hydrated very quickly, reaching high percentage of swelling after just few minutes (5 min for SCMC, 2 min for HPMC and 30 min for chitosan). Moreover, the SCMC and HPMC films were dissolved whereas chitosan was not dissolved. Dissolution also leads to viscous liquids with a higher retention time over mucosal surfaces what may lead to adhesive interactions. In vitro permeation studies showed that for all the formulations studied, SCMC (19.91%), HPMC (69.5%) and chitosan (24.17%), the percentage of drug permeated increased compared to the drug solution (8.26%). Specifically the HPMC film presents greater amounts of doxepin permeated (49.27 ± 4.47 mg/cm 2 ).

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Design of Meloxicam and Lornoxicam Transdermal Patches: Preparation, Physical Characterization, ex Vivo and in Vivo Studies

Cited by 30 publications

References 17 publications

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia

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