Organotellurium compounds as efficient retarders of lipid peroxidation in methanol

Engman, Lars; Persson, Joachim; Vessman, Kerstin; Ekström, Mikael; Berglund, Mats; Andersson, Carina

doi:10.1016/0891-5849(95)00035-v

Cited by 66 publications

(32 citation statements)

References 35 publications

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“…A common observed feature consists in the great antioxidant efficacy of tellurium derivatives in comparison to sulfur or selenium analogues. It is noteworthy that diaryl tellurides inhibit lipid peroxidation much longer than conventional antioxidants, indicating an autocatalytic mechanism of antioxidant activity (Engman et al 1995). The antioxidant properties of organotel-lurium compounds were also demonstrated in complex cellular systems, in which the abrogation of radical chain reactions and the decomposition of peroxides were observed (Wieslander et al 1998).…”

Section: Biological Effects Of Organotellurium Compoundsmentioning

confidence: 88%

A glimpse on biological activities of tellurium compounds

Cunha

Gouvêa

Juliano

2009

An. Acad. Bras. Ciênc.

165

113

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Tellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date. Besides of that, the biological effects of elemental tellurium and some of its inorganic and organic derivatives have been studied, leading to a set of interesting and promising applications. As an example, it can be highlighted the uses of alkali-metal tellurites and tellurates in microbiology, the antioxidant effects of organotellurides and diorganoditellurides and the immunomodulatory effects of the non-toxic inorganic tellurane, named AS-101, and the plethora of its uses. Inasmuch, the nascent applications of organic telluranes (organotelluranes) as protease inhibitors and its applications in disease models are the most recent contribution to the scenario of the biological effects and applications of tellurium and its compounds discussed in this manuscript.

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Section: Biological Effects Of Organotellurium Compoundsmentioning

confidence: 88%

A glimpse on biological activities of tellurium compounds

Cunha

Gouvêa

Juliano

2009

An. Acad. Bras. Ciênc.

165

113

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“…Due to their ready one electron oxidation, diaryl tellurides were also found to act as chain-breaking donating antioxidants. 5,6 This antioxidative action also results in oxidation of the chalcogen atom to the stable tetravalent state. Because many mild reducing agents are known to reduce tetravalent tellurium to the divalent state, it should be possible to use organotelluriums as catalytic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Stabilization of PACREL� by organotellurium compound

Malmström

Engman

Bellander

et al. 1998

J. Appl. Polym. Sci.

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ABSTRACT:The addition of 0.17-0.50% of bis [4-(dimethylamino)phenyl]telluride to the thermoplastic elastomer PACREL significantly improved tensile strength and elongation at break in unaged and oven-aged samples. Chemiluminescence measurements showed that the organotellurium compound considerably prolonged the induction period of thermooxidation of the material and drastically reduced the total luminescence intensity of unaged and aged samples. These results indicate that the improved mechanical properties of diaryl telluride stabilized PACREL can be attributed to the antioxidative (peroxide decomposing, chain breaking) properties of the stabilizer.

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“…More recently, the researchers have focused on the ability of these compounds to act as antioxidants (Jacob et al, 2000;Kanski et al, 2001, Savegnago et al, 2006 and as retarders of lipid peroxidation (Engman et al, 1995). This property could be mediated by their glutathione peroxidase (GPX)-like activity, because organotellurium compounds are readily oxidized from the divalent to δ-ALA-D activity of prepared vinylic telluride derivatives, in vitro.…”

Section: Introductionmentioning

confidence: 99%

Vinylic telluride derivatives as promising pharmacological compounds with low toxicity

Borges

Savegnago

Pinton

et al. 2008

J of Applied Toxicology

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The aim of the present study was to evaluate pharmacological and toxicological properties of (Z)-2-(methylthio)-1-(butyltelluro)-1-phenylethene 1a, (Z)-1-(4-methylphenylsulfonyl)-2-(phenyltelluro)-2-phenylethene 1b, (Z)-2-(butyltelluro)-1-(benzylthio)-1-heptene 1c and (Z)-2-(phenylthio)-1-(butyltelluro)-1-phenylethene 1d. In vitro, vinylic telluride derivatives 1a, 1d and 1c were more effective in reducing lipid peroxidation than compound 1b. The maximal inhibitory effect of vinylic telluride derivatives on lipid peroxidation was in the following order: 1a = 1d > 1c > 1b. Compound 1b was more potent in inhibiting delta-ALA-D activity (delta-aminolevulinate dehydratase) than compounds 1c and 1d. Based on the in vitro properties presented by compounds 1a (an antioxidant) and 1b (a pro-oxidant), toxicological parameters were assessed in vivo and ex vivo in rats. Calculated LD50 of compounds 1a and 1b, administered by oral route, were 20.5 and 1.44 micromol kg(-1), respectively. Compound 1b induced behavioral alterations in the open field test. Renal and spleenic delta-ALA-D activities were inhibited in rats treated orally with compound 1a. Compound 1b stimulated delta-ALA-D activity in liver and spleen of rats. Rats treated with compound 1b had increased hepatic, renal and spleenic lipid peroxidation. Renal and hepatic markers were not altered when compounds 1a and 1b were administered to rats at doses of around LD50, while compound 1a at high doses changed aspartate aminotransferase activity and urea levels. Based on in vitro results, this study demonstrated that compounds 1a and 1d are promising antioxidant compounds. Ex vivo data reinforce compound 1a as a promising drug for more detailed pharmacological studies.

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Organotellurium compounds as efficient retarders of lipid peroxidation in methanol

Cited by 66 publications

References 35 publications

A glimpse on biological activities of tellurium compounds

A glimpse on biological activities of tellurium compounds

Stabilization of PACREL� by organotellurium compound

Vinylic telluride derivatives as promising pharmacological compounds with low toxicity

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