Organosilane as potent HIV-1 protease inhibitors and its hybrid silica nanoparticles as a “turn-off” fluorescent sensor for silver ion recognition

Singh, Gurjaspreet; Mohit, .; Diksha, .; Pawan, -; Satija, Pinky; Sushma, .; Sharma, Sanjay; Gupta, Sofia; Singh, K.

doi:10.1016/j.ica.2022.121263

Cited by 11 publications

(3 citation statements)

References 34 publications

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“…The docked structures and interactions at the active sites were visualized using Discovery Studio Visualizer v20.1.0.19295. 32…”

Section: Methodsmentioning

confidence: 99%

Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu²⁺ ion detection: unravelling logic gate behaviour and molecular docking studies

Singh,

Mohit,

Singh

et al. 2024

New J. Chem.

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“…The docked structures and interactions at the active sites were visualized using Discovery Studio Visualizer v20.1.0.19295. 32…”

Section: Methodsmentioning

confidence: 99%

Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu²⁺ ion detection: unravelling logic gate behaviour and molecular docking studies

Singh,

Mohit,

Singh

et al. 2024

New J. Chem.

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“…The precise cleavage of these precursor proteins at specific sites by HIV-1 protease is essential for generating structural and functional proteins vital for the assembly of new viral particles. Without the activity of HIV-1 protease, the virus fails to mature properly, leading to significant impairment of its replication [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Protease inhibitors, a class of antiretroviral drugs, specifically target HIV-1 protease, disrupting its proper functioning. By inhibiting the activity of HIV-1 protease, these drugs effectively suppress viral replication, contributing to the management of HIV infection, especially when used in combination therapy [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study<strong> </strong>

Ferrari

2024

Preprint

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This study investigates the potential of natural compounds against HIV-1 protease, a critical enzyme in the replication cycle of human immunodeficiency virus type 1 (HIV-1). HIV-1 protease is essential for cleaving large precursor proteins into smaller functional proteins necessary for viral maturation and infectivity. Protease inhibitors, specifically targeting HIV-1 protease, effectively suppress viral replication, aiding in the management of HIV infection. Using the SWISS DOCK Server, several natural compounds were investigated for their potential as inhibitors of HIV-1 protease. Docking results revealed that Amentoflavone showed excellent binding affinity with high Estimated ΔG values, suggesting its potential as an inhibitor of HIV-1 protease. Additionally, Amentoflavone exhibited similar promising results when tested against Roussarcoma virus protease. These findings indicate the potential of Amentoflavone as a natural compound against HIV and warrant further investigation into its therapeutic applications.

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Organosilane as a versatile compound: Silica-Based nanoparticles for detection of methyl parathion and inhibition of acetylcholinesterase (AChE) in Alzheimer’s disease

Singh

Gupta

Sharma

et al. 2023

Environmental Nanotechnology, Monitoring & Management

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Organosilane as potent HIV-1 protease inhibitors and its hybrid silica nanoparticles as a “turn-off” fluorescent sensor for silver ion recognition

Cited by 11 publications

References 34 publications

Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu²⁺ ion detection: unravelling logic gate behaviour and molecular docking studies

Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu²⁺ ion detection: unravelling logic gate behaviour and molecular docking studies

Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study<strong> </strong>

Organosilane as a versatile compound: Silica-Based nanoparticles for detection of methyl parathion and inhibition of acetylcholinesterase (AChE) in Alzheimer’s disease

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Organosilane as potent HIV-1 protease inhibitors and its hybrid silica nanoparticles as a “turn-off” fluorescent sensor for silver ion recognition

Cited by 11 publications

References 34 publications

Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu2+ ion detection: unravelling logic gate behaviour and molecular docking studies

Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu2+ ion detection: unravelling logic gate behaviour and molecular docking studies

Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study<strong> </strong>

Organosilane as a versatile compound: Silica-Based nanoparticles for detection of methyl parathion and inhibition of acetylcholinesterase (AChE) in Alzheimer’s disease

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Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu²⁺ ion detection: unravelling logic gate behaviour and molecular docking studies

Benzimidazole-modified organosilane functionalized silica nanoparticles as a ‘turn-off’ fluorescent probe for highly selective Cu²⁺ ion detection: unravelling logic gate behaviour and molecular docking studies