2019
DOI: 10.1186/s40168-019-0635-4
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Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota

Abstract: BackgroundDisruption of the gut microbiota homeostasis may induce low-grade inflammation leading to obesity-associated diseases. A major protective mechanism is to use the multi-layered mucus structures to keep a safe distance between gut epithelial cells and microbiota. To investigate whether pesticides would induce insulin resistance/obesity through interfering with mucus-bacterial interactions, we conducted a study to determine how long-term exposure to chlorpyrifos affected C57Bl/6 and CD-1 (ICR) mice fed … Show more

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Cited by 171 publications
(132 citation statements)
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“…Liang et al also studied the effect of a similar diet containing chlorpyrifos on mice. Subsequently, antibiotic treatment and microflora transplantation were performed [23]. The results of the experiment showed a violation of the intestinal barrier by chlorpyrifos, which led to increased penetration of lipopolysaccharides into the body and, consequently, the appearance of inflammation in the intestine.…”
Section: The Effect Of Pesticides On the Microbiome Of Model Organismsmentioning
confidence: 99%
“…Liang et al also studied the effect of a similar diet containing chlorpyrifos on mice. Subsequently, antibiotic treatment and microflora transplantation were performed [23]. The results of the experiment showed a violation of the intestinal barrier by chlorpyrifos, which led to increased penetration of lipopolysaccharides into the body and, consequently, the appearance of inflammation in the intestine.…”
Section: The Effect Of Pesticides On the Microbiome Of Model Organismsmentioning
confidence: 99%
“…These will be added to future versions of the survey. Additionally, possible pesticide exposure [57] will be added. A question asking "How often do you choose organic fruits and vegetables", with the options "Always/Mostly/Sometimes/Never" will be added.…”
Section: Discussionmentioning
confidence: 99%
“…Three studies in rodents (in ICR, C57Bl/6, and CD-1 mice and Wistar rats) showed that exposure to pesticides (carbendazim, chlorpyrifos, and organophosphorus pesticides) induces dysbiosis in the microbiota and inflammation, leading to an alteration of lipid metabolism and triggering obesity in exposed rodents [69,70,73].…”
Section: Pesticidesmentioning
confidence: 99%